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Effect of pulmonary artery pressure on extravascular lung water in an experimental model of acute lung injury

Colmenero, M. ; Pérez Villares, J. M. ; Fernández Sacristán, M. A. ; Garcia Delgado, M. ; Fernández Mondéjar, E.

Acta anaesthesiologica Scandinavica, 2005-11, Vol.49 (10), p.1449-1455 [Peer Reviewed Journal]

Oxford, UK; Malden, USA: Blackwell Publishing Ltd/Inc

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Title:
Effect of pulmonary artery pressure on extravascular lung water in an experimental model of acute lung injury
Author: Colmenero, M. ; Pérez Villares, J. M. ; Fernández Sacristán, M. A. ; Garcia Delgado, M. ; Fernández Mondéjar, E.
Subjects: Acute Disease ; acute lung injury ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Cardiac Output - physiology ; extravascular lung water ; Extravascular Lung Water - physiology ; Hemodynamics - physiology ; mechanical ventilation ; Medical sciences ; Oxygen - blood ; Pilot Projects ; Pulmonary Edema - physiopathology ; Pulmonary Gas Exchange - physiology ; pulmonary hypertension ; Pulmonary Wedge Pressure - physiology ; Respiratory Mechanics - physiology ; Swine
Is Part Of: Acta anaesthesiologica Scandinavica, 2005-11, Vol.49 (10), p.1449-1455
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Description: Background: Lung edema can be influenced by hemodynamic changes in pulmonary circulation. The aim of this study was to evaluate, in an experimental model of acute lung injury, the effect on extravascular lung water (EVLW) of an increase in pulmonary artery pressure (Ppa) without changes in cardiac output and wedge pressure. Methods: Lung edema was produced by an intravenous oleic acid infusion in mixed‐breed pigs weighing 25–31 kg, which, after 20 min, were randomly assigned to a control group (100% FiO2) (n = 6) or a high Ppa group (21% FiO2) (n = 7). An increase in pulmonary artery pressure of at least 40% over baseline was produced in the high Ppa group by alveolar hypoxia. Hemodynamic, ventilatory and gas exchange parameters were collected at regular intervals. Pulmonary, wedge and capillary pressures were measured with a pulmonary artery catheter and the occlusion technique. EVLW was calculated gravimetrically. Results: At 240 min, both gravimetric‐measured EVLW and mean pulmonary artery pressures were significantly higher (P < 0.05) in high Ppa animals vs. controls (12.06 ± 4.21 vs. 7.98 ± 2.46 ml/kg and 39.0 ± 1.3 vs. 26.6 ± 4.7 mmHg, respectively). Cardiac output (6.8 ± 2.5 vs. 7.3 ± 1.3) and pulmonary wedge pressures (9.2 ± 1.7 vs. 9.4 ± 2.8 mmHg) were similar. A difference was detected in pulmonary capillary pressures [17.0 ± 3.3 (high Ppa) vs. 13.8 ± 2.7 mmHg (controls)] but did not reach statistical significance. Conclusions: In this model, an increase in pulmonary artery pressure by alveolar hypoxia produces an increase in extravascular lung water, probably related to changes in pulmonary capillary pressures.
Publisher: Oxford, UK; Malden, USA: Blackwell Publishing Ltd/Inc
Language: English

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Effect of pulmonary artery pressure on extravascular lung water in an experimental model of acute lung injury

Colmenero, M. ; Pérez Villares, J. M. ; Fernández Sacristán, M. A. ; Garcia Delgado, M. ; Fernández Mondéjar, E.

Oxford, UK; Malden, USA: Blackwell Publishing Ltd/Inc

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