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Antihypertensive effect of angiotensin I-converting enzyme inhibitory peptides from a sesame [Sesamum indicum] protein hydrolysate in spontaneously hypertensive rats

Nakano, D.(Osaka Univ. of Pharmaceutical Sciences, Takatsuki (Japan)) ; Ogura, K ; Miyakoshi, M ; Ishii, F ; Kawanishi, H ; Kurumazuka, D ; Kwak, C.J ; Ikemura, K ; Takaoka, M ; Moriguchi, S ; Iino, T ; Kusumoto, A ; Asami, S ; Shibata, H ; Kiso, Y ; Matsumura, Y

Bioscience, biotechnology, and biochemistry, 2006-05, Vol.70 (5), p.1118-1126 [Periódico revisado por pares]

Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry

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Título:
Antihypertensive effect of angiotensin I-converting enzyme inhibitory peptides from a sesame [Sesamum indicum] protein hydrolysate in spontaneously hypertensive rats
Autor: Nakano, D.(Osaka Univ. of Pharmaceutical Sciences, Takatsuki (Japan)) ; Ogura, K ; Miyakoshi, M ; Ishii, F ; Kawanishi, H ; Kurumazuka, D ; Kwak, C.J ; Ikemura, K ; Takaoka, M ; Moriguchi, S ; Iino, T ; Kusumoto, A ; Asami, S ; Shibata, H ; Kiso, Y ; Matsumura, Y
Assuntos: Administration, Oral ; Amino Acid Sequence ; angiotensin I-converting enzyme ; Angiotensin-Converting Enzyme Inhibitors - chemistry ; Angiotensin-Converting Enzyme Inhibitors - isolation & purification ; Angiotensin-Converting Enzyme Inhibitors - pharmacology ; Animals ; Antihypertensive Agents - chemistry ; Antihypertensive Agents - isolation & purification ; Antihypertensive Agents - pharmacology ; Biological and medical sciences ; Blood Pressure - drug effects ; CARDIOVASCULAR AGENTS ; ENZYME INHIBITORS ; Fundamental and applied biological sciences. Psychology ; HIPERTENSION ; Hydrolysis ; HYPERTENSION ; Hypertension - enzymology ; INHIBIDORES DE ENZIMAS ; INHIBITEUR D'ENZYME ; MEDICAMENTOS CARDIOVASCULARES ; MODIFICATEUR CARDIOVASCULAIRE ; Oligopeptides - chemistry ; Oligopeptides - isolation & purification ; Oligopeptides - pharmacology ; oral administration ; PEPTIDASAS ; PEPTIDASE ; PEPTIDASES ; PEPTIDE ; PEPTIDES ; PEPTIDOS ; Peptidyl-Dipeptidase A - drug effects ; Plant Preparations - administration & dosage ; Plant Preparations - chemistry ; Plant Proteins - chemistry ; Plant Proteins - isolation & purification ; RAT ; RATA ; RATS ; Rats, Inbred SHR ; sesame peptide ; Sesamum - chemistry ; SESAMUM INDICUM ; spontaneously hypertensive rat
É parte de: Bioscience, biotechnology, and biochemistry, 2006-05, Vol.70 (5), p.1118-1126
Notas: S20
2007003587
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Sesame peptide powder (SPP) exhibited angiotensin I-converting enzyme (ACE) inhibitory activity, and significantly and temporarily decreased the systolic blood pressure (SBP) in spontaneously hypertensive rats (SHRs) by a single administration (1 and 10mg/kg). Six peptide ACE inhibitors were isolated and identified from SPP. The representative peptides, Leu-Val-Tyr, Leu-Gln-Pro and Leu-Lys-Tyr, could competitively inhibit ACE activity at respective Ki values of 0.92 microM, 0.50 microM, and 0.48 microM. A reconstituted sesame peptide mixture of Leu-Ser-Ala, Leu-Gln-Pro, Leu-Lys-Tyr, Ile-Val-Tyr, Val-Ile-Tyr, Leu-Val-Tyr, and Met-Leu-Pro-Ala-Tyr according to their content ratio in SPP showed a strong antihypertensive effect on SHR at doses of 3.63 and 36.3 microg/kg, which accounted for more than 70% of the corresponding dosage for the SPP-induced hypotensive effect. Repeated oral administration of SPP also lowered both SBP and the aortic ACE activity in SHR. These results demonstrate that SPP would be a beneficial ingredient for preventing and providing therapy against hypertension and its related diseases.
Editor: Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry
Idioma: Inglês

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Antihypertensive effect of angiotensin I-converting enzyme inhibitory peptides from a sesame [Sesamum indicum] protein hydrolysate in spontaneously hypertensive rats

Nakano, D.(Osaka Univ. of Pharmaceutical Sciences, Takatsuki (Japan)) ; Ogura, K ; Miyakoshi, M ; Ishii, F ; Kawanishi, H ; Kurumazuka, D ; Kwak, C.J ; Ikemura, K ; Takaoka, M ; Moriguchi, S ; Iino, T ; Kusumoto, A ; Asami, S ; Shibata, H ; Kiso, Y ; Matsumura, Y

Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry

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