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Escitalopram prolonged fear induced by simulated public speaking and released hypothalamic-pituitary-adrenal axis activation

Garcia-Leal, C. ; Del-Ben, CM ; Leal, FM ; Graeff, FG ; Guimarães, FS

Journal of psychopharmacology (Oxford), 2010-05, Vol.24 (5), p.683-694 [Periódico revisado por pares]

London, England: SAGE Publications

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Título:
Escitalopram prolonged fear induced by simulated public speaking and released hypothalamic-pituitary-adrenal axis activation
Autor: Garcia-Leal, C. ; Del-Ben, CM ; Leal, FM ; Graeff, FG ; Guimarães, FS
Assuntos: Adrenal glands ; Adult ; Adult and adolescent clinical studies ; Affect - drug effects ; Affect - physiology ; Antidepressants ; Antidepressive Agents, Second-Generation - administration & dosage ; Antidepressive Agents, Second-Generation - adverse effects ; Anxiety ; Anxiety disorders. Neuroses ; Autonomic nervous system ; Biological and medical sciences ; Citalopram ; Citalopram - administration & dosage ; Citalopram - adverse effects ; Citalopram - blood ; Cortisol ; Dose-Response Relationship, Drug ; Double-Blind Method ; Fear ; Fear - drug effects ; Galvanic Skin Response - drug effects ; Hemodynamics - drug effects ; Humans ; Hydrocortisone - blood ; Hypothalamic-pituitary-adrenal axis ; Hypothalamo-Hypophyseal System - physiopathology ; Hypothalamus ; Male ; Males ; Medical sciences ; Neuropharmacology ; Neurotransmission ; Panic ; Panic disorder ; Pharmacology. Drug treatments ; Pituitary ; Pituitary-Adrenal System - physiopathology ; Prolactin ; Prolactin - blood ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychopharmacology ; Serotonin ; Serotonin - physiology ; Serotonin uptake inhibitors ; Serotonin Uptake Inhibitors - administration & dosage ; Serotonin Uptake Inhibitors - adverse effects ; Speech ; Speech - physiology ; Surveys and Questionnaires ; Time Factors ; Young Adult
É parte de: Journal of psychopharmacology (Oxford), 2010-05, Vol.24 (5), p.683-694
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Descrição: Simulated public speaking (SPS) test is sensitive to drugs that interfere with serotonin-mediated neurotransmission and is supposed to recruit neural systems involved in panic disorder. The study was aimed at evaluating the effects of escitalopram, the most selective serotonin-selective reuptake inhibitor available, in SPS. Healthy males received, in a double-blind, randomized design, placebo (n = 12), 10 (n = 17) or 20 (n = 14) mg of escitalopram 2 hours before the test. Behavioural, autonomic and neuroendocrine measures were assessed. Both doses of escitalopram did not produce any effect before or during the speech but prolonged the fear induced by SPS. The test itself did not significantly change cortisol and prolactin levels but under the higher dose of escitalopram, cortisol and prolactin increased immediately after SPS. This fear-enhancing effect of escitalopram agrees with previously reported results with less selective serotonin reuptake inhibitors and the receptor antagonist ritanserin, indicating that serotonin inhibits the fear of speaking in public.
Editor: London, England: SAGE Publications
Idioma: Inglês

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Escitalopram prolonged fear induced by simulated public speaking and released hypothalamic-pituitary-adrenal axis activation

Garcia-Leal, C. ; Del-Ben, CM ; Leal, FM ; Graeff, FG ; Guimarães, FS

London, England: SAGE Publications

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