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Initiation of cell proliferation in cultured mouse fibroblasts by prostaglandin F2alpha

De Asua, L J ; Clingan, D ; Rudland, P S

Proceedings of the National Academy of Sciences - PNAS, 1975-07, Vol.72 (7), p.2724-2728 [Periódico revisado por pares]

United States: National Acad Sciences

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Título:
Initiation of cell proliferation in cultured mouse fibroblasts by prostaglandin F2alpha
Autor: De Asua, L J ; Clingan, D ; Rudland, P S
Assuntos: Animals ; Arachidonic Acids - pharmacology ; Cattle ; Cell Division - drug effects ; Cells, Cultured ; Culture Media ; Cyclic AMP - metabolism ; Cyclic GMP - metabolism ; DNA Replication - drug effects ; Eledoisin - pharmacology ; Fibroblasts - drug effects ; Fibroblasts - metabolism ; Insulin - pharmacology ; Linoleic Acids - pharmacology ; Mice ; Oxytocin - pharmacology ; Prostaglandins E - pharmacology ; Prostaglandins F - pharmacology
É parte de: Proceedings of the National Academy of Sciences - PNAS, 1975-07, Vol.72 (7), p.2724-2728
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Prostaglandin (PG) F2alpha added to quiescent Swiss mouse 3T3 cell cultures initiates DNA synthesis and cell proliferation in a small proportion of the cells. Insulin, which markedly potentiates the effect of PGF2alpha on the initiation of cell division when added with PGF2alpha, causes a simultaneous reduction in intracellular cyclic AMP and an increase in cyclic GMP concentrations similar to those observed after serum addition. Prostaglandins E1 and E2 are less effective than PGF2alpha in initiating DNA synthesis and this effect is only observed at higher concentrations. Therefore, some prostaglandins can act as extracellular factors to regulate cell proliferation.
Editor: United States: National Acad Sciences
Idioma: Inglês

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Initiation of cell proliferation in cultured mouse fibroblasts by prostaglandin F2alpha

De Asua, L J ; Clingan, D ; Rudland, P S

United States: National Acad Sciences

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