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Allergic Reactions to Oxaliplatin in a Single Institute in Japan

Ichikawa, Yasushi ; Goto, Ayumu ; Hirokawa, Satoru ; Kijima, Miyuki ; Ishikawa, Takashi ; Chishima, Takashi ; Suwa, Hirokazu ; Yamamoto, Harumi ; Yamagishi, Shigeru ; Osada, Shunichi ; Ota, Mitsuyoshi ; Fujii, Shoichi

Japanese journal of clinical oncology, 2009-09, Vol.39 (9), p.616-620 [Periódico revisado por pares]

England: Oxford University Press

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Título:
Allergic Reactions to Oxaliplatin in a Single Institute in Japan
Autor: Ichikawa, Yasushi ; Goto, Ayumu ; Hirokawa, Satoru ; Kijima, Miyuki ; Ishikawa, Takashi ; Chishima, Takashi ; Suwa, Hirokazu ; Yamamoto, Harumi ; Yamagishi, Shigeru ; Osada, Shunichi ; Ota, Mitsuyoshi ; Fujii, Shoichi
Assuntos: Aged ; allergy ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Drug Hypersensitivity - etiology ; Female ; Fluorouracil - adverse effects ; FOLFOX ; Humans ; hypoxemia ; Japan ; Leucovorin - adverse effects ; Male ; Medical Records ; Middle Aged ; Neoplasms - drug therapy ; Neoplasms - pathology ; Organoplatinum Compounds - adverse effects ; oxaliplatin ; Prognosis ; Retrospective Studies ; Risk Factors ; Survival Rate
É parte de: Japanese journal of clinical oncology, 2009-09, Vol.39 (9), p.616-620
Notas: ArticleID:hyp070
istex:8BA0D6B5D2BA7921F82D655E7BB8BE70A56D223F
ark:/67375/HXZ-G3KHHFJZ-G
Descrição: Allergic reactions to oxaliplatin can be severe and are an important cause of discontinuation of treatment. A retrospective review was performed for 105 patients who received FOLFOX regimens between May 2005 and June 2007. Twenty-five cases (23.8%) of allergic reactions were identified, including 9 late onset reactions (8.6%) and 16 immediate reactions (15.2%). Severe allergy (Grades 3 and 4) occurred in seven patients (6.7%). Re-introduction of FOLFOX was attempted for seven immediate onset patients with a severity grade of 1 or 2, and three of these patients (42.9%) showed relapse of allergy. In ∼10% of the patients, FOLFOX had to be discontinued due to allergy before the disease became refractory to the regimen. Our experience indicates that allergy to oxaliplatin may be a significant concern and that methods are required for suppression of this allergy.
Editor: England: Oxford University Press
Idioma: Inglês

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Allergic Reactions to Oxaliplatin in a Single Institute in Japan

Ichikawa, Yasushi ; Goto, Ayumu ; Hirokawa, Satoru ; Kijima, Miyuki ; Ishikawa, Takashi ; Chishima, Takashi ; Suwa, Hirokazu ; Yamamoto, Harumi ; Yamagishi, Shigeru ; Osada, Shunichi ; Ota, Mitsuyoshi ; Fujii, Shoichi

England: Oxford University Press

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