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The association of caffeine and nandrolone decanoate modulates aversive memory and nociception in rats

Penna, Daniel Bussinger de Souza ; Gumiéro Costa, Samara ; dos Santos-Rodrigues, Alexandre ; Pandolfo, Pablo

Brain research, 2024-08, Vol.1837, p.148937-148937, Article 148937 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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  • Título:
    The association of caffeine and nandrolone decanoate modulates aversive memory and nociception in rats
  • Autor: Penna, Daniel Bussinger de Souza ; Gumiéro Costa, Samara ; dos Santos-Rodrigues, Alexandre ; Pandolfo, Pablo
  • Assuntos: Anabolic androgenic steroids ; Animal model ; Aversive memory ; Behavior ; Caffeine ; Nandrolone decanoate ; Nociception ; Sex differences
  • É parte de: Brain research, 2024-08, Vol.1837, p.148937-148937, Article 148937
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: •Nandrolone decanoate (ND) is a widely abused anabolic androgenic steroid.•Caffeineis a non-selective antagonist of adenosine receptors.•The combination of ND and caffeine induces fear memory in female rats.•Caffeine produces antinociceptive responses in both males and females. Caffeine and anabolic–androgenic steroids (AAS) are commonly used to improve muscle mass and athletic performance. Nandrolone Decanoate (ND) is one of the most abused AAS worldwide, leading to behavioral changes in both humans and rodents. Caffeine, the most widely consumed psychostimulant globally, is present in various thermogenic and gym supplements. Low and moderate doses of caffeine antagonize adenosine receptors and have been linked to improved memory and pain relief. We have previously demonstrated that consuming caffeine prevents the risk-taking behavior triggered by nandrolone. In this study, we aimed to investigate the long-term effects of ND and caffeine, either alone or in combination, on passive avoidance memory and nociception. We used the step-down and hot-plate tasks in male and female Lister Hooded rats. Our results confirmed the antinociceptive effect of caffeine and indicated that chronic administration of the ND-caffeine association promotes the evocation of aversive memory in female rats.
  • Editor: Netherlands: Elsevier B.V
  • Idioma: Inglês
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