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Spatiotemporal resolution of BDNF neuroprotection against glutamate excitotoxicity in cultured hippocampal neurons

Melo, C.V ; Okumoto, S ; Gomes, J.R ; Baptista, M.S ; Bahr, B.A ; Frommer, W.B ; Duarte, C.B

Neuroscience, 2013-05, Vol.237, p.66-86 [Periódico revisado por pares]

Amsterdam: Elsevier Ltd

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Título:
Spatiotemporal resolution of BDNF neuroprotection against glutamate excitotoxicity in cultured hippocampal neurons
Autor: Melo, C.V ; Okumoto, S ; Gomes, J.R ; Baptista, M.S ; Bahr, B.A ; Frommer, W.B ; Duarte, C.B
Assuntos: Amino Acid Chloromethyl Ketones - pharmacology ; Animals ; axons ; Axons - drug effects ; Axons - metabolism ; Biological and medical sciences ; brain-derived neurotrophic factor (BDNF) ; Brain-Derived Neurotrophic Factor - pharmacology ; Calpain - metabolism ; Cells, Cultured ; dendrites ; Down-Regulation - drug effects ; Drug Interactions ; Embryo, Mammalian ; Enzyme Inhibitors - pharmacology ; excitotoxicity ; Fundamental and applied biological sciences. Psychology ; Glutamic Acid - toxicity ; Hippocampus - cytology ; Nerve Tissue Proteins - metabolism ; Neurology ; Neurons - cytology ; Neurons - drug effects ; neuroprotection ; Neuroprotective Agents - pharmacology ; Rats ; Signal Transduction - drug effects ; synapses ; Time Factors ; TRPC Cation Channels - metabolism ; Vertebrates: nervous system and sense organs
É parte de: Neuroscience, 2013-05, Vol.237, p.66-86
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Highlights ► Caspase inhibition and pre-incubation with BDNF abrogate excitotoxicity-induced chromatin condensation. ► Proteasome/calpains contribute to excitotoxicity-induced neurite damage. ► Proteasome/calpains do not contribute to excitotoxicity-induced chromatin condensation. ► Pre-incubation with BDNF protects neurites from excitotoxic damage. ► The protective effect of BDNF in neurites is mediated by phosphatidylinositol 3-kinase and phospholipase C-γ (PLCγ).
Editor: Amsterdam: Elsevier Ltd
Idioma: Inglês

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Spatiotemporal resolution of BDNF neuroprotection against glutamate excitotoxicity in cultured hippocampal neurons

Melo, C.V ; Okumoto, S ; Gomes, J.R ; Baptista, M.S ; Bahr, B.A ; Frommer, W.B ; Duarte, C.B

Amsterdam: Elsevier Ltd

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