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Phage Therapy: a Step Forward in the Treatment of Pseudomonas aeruginosa Infections

Pires, Diana P ; Vilas Boas, Diana ; Sillankorva, Sanna ; Azeredo, Joana Goff, S. P.

Journal of virology, 2015-08, Vol.89 (15), p.7449-7456 [Periódico revisado por pares]

United States: American Society for Microbiology

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  • Título:
    Phage Therapy: a Step Forward in the Treatment of Pseudomonas aeruginosa Infections
  • Autor: Pires, Diana P ; Vilas Boas, Diana ; Sillankorva, Sanna ; Azeredo, Joana
  • Goff, S. P.
  • Assuntos: Animals ; Biological Therapy ; Disease Models, Animal ; Humans ; Minireview ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - physiology ; Pseudomonas aeruginosa - virology ; Pseudomonas Infections - microbiology ; Pseudomonas Infections - therapy ; Pseudomonas Phages - physiology
  • É parte de: Journal of virology, 2015-08, Vol.89 (15), p.7449-7456
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    ObjectType-Article-1
    ObjectType-Feature-2
    Citation Pires DP, Vilas Boas D, Sillankorva S, Azeredo J. 2015. Phage therapy: a step forward in the treatment of Pseudomonas aeruginosa infections. J Virol 89:7449–7456. doi:10.1128/JVI.00385-15.
  • Descrição: Antimicrobial resistance constitutes one of the major worldwide public health concerns. Bacteria are becoming resistant to the vast majority of antibiotics, and nowadays, a common infection can be fatal. To address this situation, the use of phages for the treatment of bacterial infections has been extensively studied as an alternative therapeutic strategy. Since Pseudomonas aeruginosa is one of the most common causes of health care-associated infections, many studies have reported the in vitro and in vivo antibacterial efficacy of phage therapy against this bacterium. This review collects data of all the P. aeruginosa phages sequenced to date, providing a better understanding about their biodiversity. This review further addresses the in vitro and in vivo results obtained by using phages to treat or prevent P. aeruginosa infections as well as the major hurdles associated with this therapy.
  • Editor: United States: American Society for Microbiology
  • Idioma: Inglês
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