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T-cell intracellular antigens in health and disease

Sánchez-Jiménez, Carmen ; Izquierdo, José M

Cell cycle (Georgetown, Tex.), 2015-07, Vol.14 (13), p.2033-2043 [Periódico revisado por pares]

United States: Taylor & Francis

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Título:
T-cell intracellular antigens in health and disease
Autor: Sánchez-Jiménez, Carmen ; Izquierdo, José M
Assuntos: Animals ; cell death ; Cell Death - physiology ; embryogenesis ; gene expression control ; Health Status ; Humans ; Intracellular Fluid - metabolism ; Poly(A)-Binding Proteins - genetics ; Poly(A)-Binding Proteins - metabolism ; proliferation ; Reviews ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; RNA-Binding Proteins - genetics ; RNA-Binding Proteins - metabolism ; T-Cell Intracellular Antigen-1 ; T-Lymphocytes - metabolism ; TIA1 ; TIAR ; tumorigenesis ; Welander
É parte de: Cell cycle (Georgetown, Tex.), 2015-07, Vol.14 (13), p.2033-2043
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: T-cell intracellular antigen 1 (TIA1) and TIA1-related/like protein (TIAR/TIAL1) are 2 proteins discovered in 1991 as components of cytotoxic T lymphocyte granules. They act in the nucleus as regulators of transcription and pre-mRNA splicing. In the cytoplasm, TIA1 and TIAR regulate and/or modulate the location, stability and/or translation of mRNAs. As knowledge of the different genes regulated by these proteins and the cellular/biological programs in which they are involved increases, it is evident that these antigens are key players in human physiology and pathology. This review will discuss the latest developments in the field, with physiopathological relevance, that point to novel roles for these regulators in the molecular and cell biology of higher eukaryotes.
Editor: United States: Taylor & Francis
Idioma: Inglês

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T-cell intracellular antigens in health and disease

Sánchez-Jiménez, Carmen ; Izquierdo, José M

United States: Taylor & Francis

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