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1% Hydrocortisone ointment is an effective treatment of pruritus ani : a pilot randomized controlled crossover trial

AL-GHNANIEM, R ; SHORT, K ; PULLEN, A ; FULLER, L. C ; RENNIE, J. A ; LEATHER, A. J. M

International journal of colorectal disease, 2007-12, Vol.22 (12), p.1463-1467, Article 1463 [Periódico revisado por pares]

Heidelberg: Springer

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Título:
1% Hydrocortisone ointment is an effective treatment of pruritus ani : a pilot randomized controlled crossover trial
Autor: AL-GHNANIEM, R ; SHORT, K ; PULLEN, A ; FULLER, L. C ; RENNIE, J. A ; LEATHER, A. J. M
Assuntos: Administration, Topical ; Adult ; Allergic diseases ; Antipruritics - administration & dosage ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Cross-Over Studies ; Double-Blind Method ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Hydrocortisone - administration & dosage ; Immunopathology ; Male ; Medical sciences ; Middle Aged ; Ointments ; Pharmacology. Drug treatments ; Pilot Projects ; Pruritus Ani - drug therapy ; Pruritus Ani - pathology ; Quality of Life ; Severity of Illness Index ; Skin - drug effects ; Skin - pathology ; Skin allergic diseases. Stinging insect allergies ; Surveys and Questionnaires ; Treatment Outcome
É parte de: International journal of colorectal disease, 2007-12, Vol.22 (12), p.1463-1467, Article 1463
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
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Descrição: Pruritus ani (PA) is a common condition which is difficult to treat in the absence of obvious predisposing factors. There is paucity of evidence-based guidelines on the treatment of this condition. We examined whether 1% hydrocortisone ointment is an effective treatment for PA. A pilot randomized, double-blind, placebo-controlled, crossover trial was carried out. Eleven patients consented to take part in the trial and ten completed the study. After a 2-week run-in period, patients with primary PA were randomly allocated to receive 1% hydrocortisone ointment or placebo for 2 weeks followed by the opposite treatment for a further 2-week period. There was a washout period of 2 weeks between treatments. The primary outcome measure was reduction in itch using a visual analogue score (VAS). The secondary outcome measures were improvement in quality of life measured using a validated questionnaire (Dermatology Life Quality Index, DLQI) and improvement in clinical appearance of the perianal skin using the Eczema Area and Severity Index (EASI) score. Treatment with 1% hydrocortisone ointment resulted in a 68% reduction in VAS compared with placebo (P=0.019), a 75% reduction in DLQI score (P=0.067), and 81% reduction in EASI score (P=0.01). A short course of mild steroid ointment is an effective treatment for PA.
Editor: Heidelberg: Springer
Idioma: Inglês

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1% Hydrocortisone ointment is an effective treatment of pruritus ani : a pilot randomized controlled crossover trial

AL-GHNANIEM, R ; SHORT, K ; PULLEN, A ; FULLER, L. C ; RENNIE, J. A ; LEATHER, A. J. M

Heidelberg: Springer

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