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High oxygen extraction and slow recovery of muscle deoxygenation kinetics after neuromuscular electrical stimulation in COPD patients

Azevedo, Diego de Paiva ; Medeiros, Wladimir Musetti ; de Freitas, Flávia Fernandes Manfredi ; Ferreira Amorim, Cesar ; Gimenes, Ana Cristina Oliveira ; Neder, Jose Alberto ; Chiavegato, Luciana Dias

European journal of applied physiology, 2016-10, Vol.116 (10), p.1899-1910 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
High oxygen extraction and slow recovery of muscle deoxygenation kinetics after neuromuscular electrical stimulation in COPD patients
Autor: Azevedo, Diego de Paiva ; Medeiros, Wladimir Musetti ; de Freitas, Flávia Fernandes Manfredi ; Ferreira Amorim, Cesar ; Gimenes, Ana Cristina Oliveira ; Neder, Jose Alberto ; Chiavegato, Luciana Dias
Assuntos: Adenosine diphosphate ; Biomedical and Life Sciences ; Biomedicine ; Blood ; Chronic obstructive pulmonary disease ; Exercise ; Female ; Hemoglobin ; Hemoglobins - metabolism ; Human Physiology ; Humans ; Kinetics ; Male ; Metabolic Clearance Rate ; Metabolism ; Middle Aged ; Muscle recovery ; Muscle Strength ; Muscle, Skeletal - physiopathology ; Muscular Atrophy - etiology ; Muscular Atrophy - physiopathology ; Muscular Atrophy - therapy ; Musculoskeletal system ; Neuromuscular electrical stimulation ; Occupational Medicine/Industrial Medicine ; Original Article ; Oxygen - metabolism ; Oxygen Consumption ; Pulmonary Disease, Chronic Obstructive - complications ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Disease, Chronic Obstructive - therapy ; Spectrum analysis ; Sports Medicine ; Transcutaneous Electric Nerve Stimulation - methods ; Treatment Outcome
É parte de: European journal of applied physiology, 2016-10, Vol.116 (10), p.1899-1910
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Descrição: Purpose It was hypothesized that patients with chronic obstructive pulmonary disease (COPD) would exhibit a slow muscle deoxygenation (HHb) recovery time when compared with sedentary controls. Methods Neuromuscular electrical stimulation (NMES 40 and 50 mA, 50 Hz, 400 µs) was employed to induce isometric contraction of the quadriceps. Microvascular oxygen extraction (µO 2 EF) and HHb were estimated by near-infrared spectroscopy (NIRS). Recovery kinetic was characterized by measuring the time constant Tau (HHb-τ). Torque and work were measured by isokinetic dynamometry in 13 non-hypoxaemic patients with moderate-to-severe COPD [SpO 2 = 94.1 ± 1.6 %; FEV 1 (% predict) 48.0 ± 9.6; GOLD II–III] and 13 age- and sex-matched sedentary controls. Results There was no desaturation in either group during NMES. Torque and work were reduced in COPD versus control for 40 and 50 mA [torque (Nm) 50 mA = 28.9 ± 6.9 vs 46.1 ± 14.2; work (J) 50 mA = 437.2 ± 130.0 vs. 608.3 ± 136.8; P < 0.05 for all]. High µO 2 EF values were observed in the COPD group at both NMES intensities (corrected by muscle mass 50 mA = 6.18 ± 1.1 vs. 4.68 ± 1.0 %/kg; corrected by work 50 mA = 0.12 ± 0.05 vs. 0.07 ± 0.02 %/J; P < 0.05 for all). Absolute values of HHb-τ (50 mA = 31.11 ± 9.27 vs. 18.08 ± 10.70 s), corrected for muscle mass (50 mA 3.80 ± 1.28 vs. 2.05 ± 1.45 s/kg) and corrected for work (50 mA = 0.08 ± 0.04 vs. 0.03 ± 0.02 s/J) were reduced in COPD ( P < 0.05 for all). The variables behaviour for 40 mA was similar to those of 50 mA. Conclusions COPD patients exhibited a slower muscle deoxygenation recovery time after NMES. The absence of desaturation, low torque and work, high µO 2 EF and high values for recovery time corrected by muscle mass and work suggest that intrinsic muscle dysfunction has an impact on muscle recovery capacity.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

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High oxygen extraction and slow recovery of muscle deoxygenation kinetics after neuromuscular electrical stimulation in COPD patients

Azevedo, Diego de Paiva ; Medeiros, Wladimir Musetti ; de Freitas, Flávia Fernandes Manfredi ; Ferreira Amorim, Cesar ; Gimenes, Ana Cristina Oliveira ; Neder, Jose Alberto ; Chiavegato, Luciana Dias

Berlin/Heidelberg: Springer Berlin Heidelberg

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