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Highlights of three metabolites HDL and reduction in blood pressure values after dietary fiber supplementation in overweight and obese normotensive women: a metabolomic study

da Silva, Cássia Surama Oliveira ; Monteiro, Mussara Gomes Cavalcanti Alves ; Fechine, Carla Patricia Novaes dos Santos ; Tavares, Josean Fechine ; Souto, Augusto Lopes ; Luna, Rafaella Cristhine Pordeus ; Pimenta, Flávia Cristina Fernandes ; e Silva, Ana Herminia Andrade ; da Silva Diniz, Alcides ; da Silva Júnior, Celso Costa ; Alverga, Caio César Ferreira ; dos Santos, Sócrates Golzio ; Persuhn, Darlene Camati ; de Carvalho Costa, Maria José

Metabolomics, 2023-11, Vol.19 (12), p.95-95, Article 95 [Periódico revisado por pares]

New York: Springer US

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Título:
Highlights of three metabolites HDL and reduction in blood pressure values after dietary fiber supplementation in overweight and obese normotensive women: a metabolomic study
Autor: da Silva, Cássia Surama Oliveira ; Monteiro, Mussara Gomes Cavalcanti Alves ; Fechine, Carla Patricia Novaes dos Santos ; Tavares, Josean Fechine ; Souto, Augusto Lopes ; Luna, Rafaella Cristhine Pordeus ; Pimenta, Flávia Cristina Fernandes ; e Silva, Ana Herminia Andrade ; da Silva Diniz, Alcides ; da Silva Júnior, Celso Costa ; Alverga, Caio César Ferreira ; dos Santos, Sócrates Golzio ; Persuhn, Darlene Camati ; de Carvalho Costa, Maria José
Assuntos: Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Blood pressure ; Body weight ; Cell Biology ; Developmental Biology ; Dietary fiber ; Dietary supplements ; High density lipoprotein ; Life Sciences ; Metabolites ; Metabolomics ; Molecular Medicine ; Obesity ; Original Article ; Overweight ; Placebos
É parte de: Metabolomics, 2023-11, Vol.19 (12), p.95-95, Article 95
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Descrição: Introduction The prevalence of hypertension and obesity are a worldwide concern. Objetives Assess the metabolites profile after intervention with mixed dietary fiber in overweight and obese normotensive women. Methods This is a randomized double blind placebo-controlled study. Through a simple randomization process, two groups were allocated, with eleven women (group 1) receiving 12 g of mixed dietary fiber and thirteen women (group 2) receiving 12 g of placebo (corn starch) for eight weeks. Anthropometric and biochemical tests and lifestyle were analyzed. As for evaluation metabolomics, used a 1 H NMR. The data matrix generated 96 samples and 225 variables, which was exported in the ASCII format for the “The Unscrumbler” statistics software (version 9.7, CAMO Process). Results After the intervention with mixed dietary fiber, significant differences were observed between the main types of metabolites, referring to the increase in the relative peak areas of in three HDL metabolites 4.94 ppm (0.0086*), HDL 1.28 ppm (0 .0337*), HDL 0.88 ppm (0.0224*) and an α-glucose metabolite 4.90 ppm (0.0106) and the reduction in systolic blood pressure (SBP) (0.0292*) of 7 mmHg in the reference range and in the placebo group there was a reduction in SBP (0.0118*) of 4 mmHg and of a choline metabolite 3.65 ppm (0.0266*), which does not call into question the validity of these results in the literature. Conclusion The synergism of the functions of these statistically highlighted metabolites contributed to prevention the increase in SBP after fiber intervention in overweight and obese normotensive women.
Editor: New York: Springer US
Idioma: Inglês

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Highlights of three metabolites HDL and reduction in blood pressure values after dietary fiber supplementation in overweight and obese normotensive women: a metabolomic study

New York: Springer US

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