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High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography

Boutet, Sébastien ; Lomb, Lukas ; Williams, Garth J. ; Barends, Thomas R. M. ; Aquila, Andrew ; Doak, R. Bruce ; Weierstall, Uwe ; DePonte, Daniel P. ; Steinbrener, Jan ; Shoeman, Robert L. ; Messerschmidt, Marc ; Barty, Anton ; White, Thomas A. ; Kassemeyer, Stephan ; Kirian, Richard A. ; Seibert, M. Marvin ; Montanez, Paul A. ; Kenney, Chris ; Herbst, Ryan ; Hart, Philip ; Pines, Jack ; Haller, Gunther ; Gruner, Sol M. ; Philipp, Hugh T. ; Tate, Mark W. ; Hromalik, Marianne ; Koerner, Lucas J. ; van Bakel, Niels ; Morse, John ; Ghonsalves, Wilfred ; Arnlund, David ; Bogan, Michael J. ; Caleman, Carl ; Fromme, Raimund ; Hampton, Christina Y. ; Hunter, Mark S. ; Johansson, Linda C. ; Katona, Gergely ; Kupitz, Christopher ; Liang, Mengning ; Martin, Andrew V. ; Nass, Karol ; Redecke, Lars ; Stellato, Francesco ; Timneanu, Nicusor ; Wang, Dingjie ; Zatsepin, Nadia A. ; Schafer, Donald ; Defever, James ; Neutze, Richard ; Fromme, Petra ; Spence, John C. H. ; Chapman, Henry N. ; Schlichting, Ilme

Science (American Association for the Advancement of Science), 2012-07, Vol.337 (6092), p.362-364 [Periódico revisado por pares]

Washington, DC: American Association for the Advancement of Science

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Título:
High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography
Autor: Boutet, Sébastien ; Lomb, Lukas ; Williams, Garth J. ; Barends, Thomas R. M. ; Aquila, Andrew ; Doak, R. Bruce ; Weierstall, Uwe ; DePonte, Daniel P. ; Steinbrener, Jan ; Shoeman, Robert L. ; Messerschmidt, Marc ; Barty, Anton ; White, Thomas A. ; Kassemeyer, Stephan ; Kirian, Richard A. ; Seibert, M. Marvin ; Montanez, Paul A. ; Kenney, Chris ; Herbst, Ryan ; Hart, Philip ; Pines, Jack ; Haller, Gunther ; Gruner, Sol M. ; Philipp, Hugh T. ; Tate, Mark W. ; Hromalik, Marianne ; Koerner, Lucas J. ; van Bakel, Niels ; Morse, John ; Ghonsalves, Wilfred ; Arnlund, David ; Bogan, Michael J. ; Caleman, Carl ; Fromme, Raimund ; Hampton, Christina Y. ; Hunter, Mark S. ; Johansson, Linda C. ; Katona, Gergely ; Kupitz, Christopher ; Liang, Mengning ; Martin, Andrew V. ; Nass, Karol ; Redecke, Lars ; Stellato, Francesco ; Timneanu, Nicusor ; Wang, Dingjie ; Zatsepin, Nadia A. ; Schafer, Donald ; Defever, James ; Neutze, Richard ; Fromme, Petra ; Spence, John C. H. ; Chapman, Henry N. ; Schlichting, Ilme
Assuntos: Animals ; Biochemistry and Molecular Biology ; Biokemi och molekylärbiologi ; Biological and medical sciences ; Crystal structure ; Crystalline structure ; Crystallography ; Crystallography, X-Ray - methods ; Crystals ; Datasets ; diffraction data ; Electron density ; Fundamental and applied biological sciences. Psychology ; Lasers ; lysozyme ; Molecular biophysics ; Molecules ; Muramidase - chemistry ; Muramidase - radiation effects ; Nano Technology ; nanocrystallography ; Nanoteknik ; Protein Conformation ; Proteins ; Radiation damage ; Radiation dosage ; Structure in molecular biology ; Synchrotrons ; Wave diffraction
É parte de: Science (American Association for the Advancement of Science), 2012-07, Vol.337 (6092), p.362-364
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Structure determination of proteins and other macromolecules has historically required the growth of high-quality crystals sufficiently large to diffract x-rays efficiently while withstanding radiation damage. We applied serial femtosecond crystallography (SFX) using an x-ray free-electron laser (XFEL) to obtain high-resolution structural information from microcrystals (less than 1 micrometer by 1 micrometer by 3 micrometers) of the well-characterized model protein lysozyme. The agreement with synchrotron data demonstrates the immediate relevance of SFX for analyzing the structure of the large group of difficult-to-crystallize molecules.
Editor: Washington, DC: American Association for the Advancement of Science
Idioma: Inglês

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High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography

Washington, DC: American Association for the Advancement of Science

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