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The prevalence of hepatitis A antibodies in HIV exposed and/or infected children and adolescents

Gouvêa, Aída F T B ; Moraes-Pinto, Maria Isabel de ; Machado, Daisy M ; Carmo, Fabiana B do ; Beltrão, Suênia C V ; Cunegundes, Kelly S ; Pessoa, Silvana D ; Weckx, Lily Yin ; Succi, Regina Célia M

Jornal de pediatria, 2005-05, Vol.81 (3), p.205-208 [Periódico revisado por pares]

Brazil

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Título:
The prevalence of hepatitis A antibodies in HIV exposed and/or infected children and adolescents
Autor: Gouvêa, Aída F T B ; Moraes-Pinto, Maria Isabel de ; Machado, Daisy M ; Carmo, Fabiana B do ; Beltrão, Suênia C V ; Cunegundes, Kelly S ; Pessoa, Silvana D ; Weckx, Lily Yin ; Succi, Regina Célia M
Assuntos: Adolescent ; Age Factors ; Brazil - epidemiology ; Child ; Child, Preschool ; Enzyme-Linked Immunosorbent Assay ; Female ; Hepatitis A - diagnosis ; Hepatitis A - epidemiology ; Hepatitis A Antibodies - blood ; Hepatitis A virus - immunology ; HIV Infections - complications ; HIV Infections - epidemiology ; Humans ; Infant ; Male ; Prevalence
É parte de: Jornal de pediatria, 2005-05, Vol.81 (3), p.205-208
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Descrição: To evaluate the prevalence of hepatitis A virus antibodies in HIV-exposed and/or HIV-infected children and adolescents. Between September 1996 and August 2002, 352 patients (200 exposed, but not HIV-infected and 152 HIV exposed and infected) were included in this study. These children and adolescents (age ranged between 1 and 14 years) were all followed up at the Pediatric AIDS Clinic of the Federal University of São Paulo (UNIFESP) and had anti-HAV antibodies determined by a commercially available ELISA method (tests for total anti-HAV antibodies and specific IgM antibodies) (Dia Sorin and Radim). Statistical analyses were done with chi-squared and t test. The prevalence of hepatitis A virus antibodies in HIV-infected and HIV-exposed, but uninfected patients was 34% and 19.7%, respectively. We noticed that in the age range between 2 years and 10 years, the group of HIV-infected children presented a higher prevalence of hepatitis A virus antibodies (35.5%) than the group of uninfected children (16.7%) (p = 0.005). In the HIV infected group, children from B and C categories had a prevalence of hepatitis A virus antibodies (40.5%) higher than N and A categories (24.1%) (p = 0.042). Mean age did not differ when children from B and C categories were compared with N and A categories (5.18 and 5.66 years, respectively) (p = 0.617). The prevalence of hepatitis A virus antibodies in HIV exposed and/or infected children and adolescents between 1 and 14 years old was 26%. Considering the possibility of HIV infection aggravation when associated with hepatitis A virus infection, we suggest that hepatitis A virus inactivated vaccine should be administered to these patients.
Editor: Brazil
Idioma: Português;Inglês

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The prevalence of hepatitis A antibodies in HIV exposed and/or infected children and adolescents

Gouvêa, Aída F T B ; Moraes-Pinto, Maria Isabel de ; Machado, Daisy M ; Carmo, Fabiana B do ; Beltrão, Suênia C V ; Cunegundes, Kelly S ; Pessoa, Silvana D ; Weckx, Lily Yin ; Succi, Regina Célia M

Brazil

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