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High‐risk human papillomavirus distribution according to human immunodeficiency virus status among women with cervical cancer in Abidjan, Côte d'Ivoire, 2018 to 2020

Boni, Simon P. ; Tenet, Vanessa ; Horo, Apollinaire ; Heideman, Daniëlle A. M. ; Bleeker, Maaike C. G. ; Tanon, Aristophane ; Mian, Boston ; Mohenou, Isidore D. ; Ekouevi, Didier K. ; Gheit, Tarik ; Didi‐Kouko Coulibaly, Judith ; Tchounga, Boris K. ; Adoubi, Innocent ; Clifford, Gary M. ; Jaquet, Antoine

International journal of cancer, 2024-03, Vol.154 (6), p.962-968 [Periódico revisado por pares]

Hoboken, USA: John Wiley & Sons, Inc

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Título:
High‐risk human papillomavirus distribution according to human immunodeficiency virus status among women with cervical cancer in Abidjan, Côte d'Ivoire, 2018 to 2020
Autor: Boni, Simon P. ; Tenet, Vanessa ; Horo, Apollinaire ; Heideman, Daniëlle A. M. ; Bleeker, Maaike C. G. ; Tanon, Aristophane ; Mian, Boston ; Mohenou, Isidore D. ; Ekouevi, Didier K. ; Gheit, Tarik ; Didi‐Kouko Coulibaly, Judith ; Tchounga, Boris K. ; Adoubi, Innocent ; Clifford, Gary M. ; Jaquet, Antoine
Assuntos: Alphapapillomavirus ; Antiretroviral drugs ; Antiretroviral therapy ; Cancer ; CD4 antigen ; Cervical cancer ; Cote d'Ivoire - epidemiology ; Côte d'Ivoire ; Female ; Health risks ; high‐risk human papillomavirus ; HIV ; HIV Infections - complications ; HIV Infections - epidemiology ; Human immunodeficiency virus ; Human papillomavirus ; Human papillomavirus 16 ; Human papillomavirus 18 ; Human Papillomavirus Viruses ; Humans ; Immune system ; Immunization ; Life Sciences ; Medical research ; Medical screening ; Middle Aged ; Papillomavirus Infections - complications ; Papillomavirus Infections - epidemiology ; Prevalence ; Santé publique et épidémiologie ; Uterine Cervical Neoplasms - epidemiology
É parte de: International journal of cancer, 2024-03, Vol.154 (6), p.962-968
Notas: Where authors are identified as personnel of the International Agency for Research on Cancer/World Health Organisation, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy or views of the International Agency for Research on Cancer/World Health Organisation.
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Descrição: As human papillomavirus (HPV) immunisation and HPV‐based cervical cancer (CC) screening programmes expand across sub‐Saharan Africa, we investigated the potential impact of human immunodeficiency virus (HIV) status on high‐risk (HR)‐HPV distribution among women with CC in Côte d'Ivoire. From July 2018 to June 2020, paraffin‐embedded CC specimens diagnosed in Abidjan, Côte d'Ivoire were systematically collected and tested for HR‐HPV DNA. Type‐specific HR‐HPV prevalence was compared according to HIV status. Of the 170 CC specimens analysed (median age 52 years, interquartile range: [43.0‐60.0]), 43 (25.3%) were from women living with HIV (WLHIV) with a median CD4 count of 526 [373‐833] cells/mm3 and 86% were on antiretroviral therapy (ART). The overall HR‐HPV prevalence was 89.4% [95% CI: 84.7‐94.1]. All were single HR‐HPV infections with no differences according to HIV status (P = .8). Among HR‐HPV‐positive CC specimens, the most prevalent HR‐HPV types were HPV16 (57.2%), HPV18 (19.7%), HPV45 (8.6%) and HPV35 (4.6%), with no significant differences according to HIV status. Altogether, infection with HPV16/18 accounted for 71.1% [95% CI: 55.9‐86.2] of CC cases in WLHIV vs 78.9% [95% CI: 71.3‐86.5] in women without HIV (P = .3). The study confirms the major role of HPV16/18 in CC in Côte d'Ivoire and should support a regional scale‐up of HPV16/18 vaccination programmes regardless of HIV status. However, vaccines targeting additional HR‐HPV types, including HPV45 and HPV35, could further decrease future CC incidence in Côte d'Ivoire, both for WLHIV and women without HIV. What's new? HIV favours the persistence of high‐risk HPV and progression of cervical intraepithelial neoplasia to cancer, with universal access to antiretroviral therapy also possibly influencing high‐risk HPV distribution. This report addresses the timely question of the contributing role of HIV infection in high‐risk HPV distribution among women with invasive cervical cancer in Côte d'Ivoire, a country highly affected by both oncogenic viruses. As Côte d'Ivoire and a growing number of other countries today scale up HPV 16/18 vaccination, here the authors confirm that this primary prevention strategy will highly benefit women in this setting, regardless of their HIV status.
Editor: Hoboken, USA: John Wiley & Sons, Inc
Idioma: Inglês

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High‐risk human papillomavirus distribution according to human immunodeficiency virus status among women with cervical cancer in Abidjan, Côte d'Ivoire, 2018 to 2020

Hoboken, USA: John Wiley & Sons, Inc

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