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Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of Resveratrol

Liu, Yeju ; You, Yuyang ; Lu, Juan ; Chen, Xi ; Yang, Zhihong

Molecules (Basel, Switzerland), 2020-11, Vol.25 (21), p.5166 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of Resveratrol
Autor: Liu, Yeju ; You, Yuyang ; Lu, Juan ; Chen, Xi ; Yang, Zhihong
Assuntos: Amino acids ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Antineoplastic Agents - pharmacokinetics ; Antineoplastic Agents - pharmacology ; Antioxidants - pharmacokinetics ; Antioxidants - pharmacology ; bioactivity ; Bioavailability ; Biological activity ; Biosynthesis ; Blood-brain barrier ; Cardiovascular disease ; Chemical synthesis ; Drug dosages ; Gene expression ; Humans ; Hydrocarbons ; Hypoglycemic Agents - pharmacology ; Inactivation, Metabolic ; Inflammation ; Intestinal Absorption ; Low molecular weights ; Medical research ; Metabolism ; Mice ; Molecular weight ; Neuroprotection ; Neuroprotective Agents - pharmacokinetics ; Neuroprotective Agents - pharmacology ; Oxidation ; Permeability ; Pharmacokinetics ; Pharmacology ; pterostilbene ; research progress ; Resveratrol ; Resveratrol - analogs & derivatives ; Review ; Stilbene ; Stilbenes - chemical synthesis ; Stilbenes - pharmacokinetics ; Stilbenes - pharmacology ; synthesis ; Therapeutic applications ; Tissue Distribution
É parte de: Molecules (Basel, Switzerland), 2020-11, Vol.25 (21), p.5166
Descrição: Pterostilbene is a natural 3,5-dimethoxy analog of resveratrol. This stilbene compound has a strong bioactivity and exists widely in and spp. Besides natural extraction, pterostilbene can be obtained by biosynthesis. Pterostilbene has become popular because of its remarkable pharmacological activities, such as anti-tumor, anti-oxidation, anti-inflammation, and neuroprotection. Pterostilbene can be rapidly absorbed and is widely distributed in tissues, but it does not seriously accumulate in the body. Pterostilbene can easily pass through the blood-brain barrier because of its low molecular weight and good liposolubility. In this review, the studies performed in the last three years on resources, synthesis, bioactivity, and pharmacokinetics of pterostilbene are summarized. This review focuses on the effects of pterostilbene on certain diseases to explore its targets, explain the possible mechanism, and look for potential therapeutic applications.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Recent Advances in Synthesis, Bioactivity, and Pharmacokinetics of Pterostilbene, an Important Analog of Resveratrol

Liu, Yeju ; You, Yuyang ; Lu, Juan ; Chen, Xi ; Yang, Zhihong

Switzerland: MDPI AG

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