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Improving usual care outcomes in major depression in youth by targeting memory specificity: A randomized controlled trial of adjunct computerized memory specificity training (c-MeST)

Hallford, David John ; Austin, David W. ; Takano, Keisuke ; Yeow, Joesph J. ; Rusanov, Danielle ; Fuller-Tyszkiewicz, Matthew ; Raes, Filip

Journal of affective disorders, 2024-08, Vol.358, p.500-512 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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  • Título:
    Improving usual care outcomes in major depression in youth by targeting memory specificity: A randomized controlled trial of adjunct computerized memory specificity training (c-MeST)
  • Autor: Hallford, David John ; Austin, David W. ; Takano, Keisuke ; Yeow, Joesph J. ; Rusanov, Danielle ; Fuller-Tyszkiewicz, Matthew ; Raes, Filip
  • Assuntos: Adolescent ; Adult ; Antidepressive Agents - therapeutic use ; Cognitive Behavioral Therapy - methods ; Counseling - methods ; Depressive Disorder, Major - therapy ; Female ; Humans ; Major depression ; Male ; Memory ; Memory specificity ; Overgeneral memory ; Randomized controlled trial ; Therapy, Computer-Assisted - methods ; Treatment Outcome ; Young Adult ; Youth
  • É parte de: Journal of affective disorders, 2024-08, Vol.358, p.500-512
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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    ObjectType-Undefined-3
  • Descrição: Extending on previous findings that computerized Memory Specificity Training (c-MeST) improves memory specificity and depressive symptoms in Major Depressive Disorder (MDD) in adults, this study aimed to assess the effects of c-MeST in youth with MDD on memory specificity and depression in addition to other treatment. Participants aged 15–25 (N = 359, 76 % female; M age = 19.2, SD = 3.1), receiving predominantly psychological therapy or counseling (85 %) and/or antidepressants (52 %) were randomized to usual care and c-MeST or usual care. Cognitive and clinical outcomes were assessed at baseline and at one, three, and six-month follow-ups. The usual care and c-MeST group reported higher memory specificity at one-month (d = 0.42, p = .022), but not at three or six months (d's < 0.15, p's > 0.05). The rate of MDE was numerically lower in the c-MeST group at each follow-up time-point, but group was not a statistically significant predictor at one month (64 % usual care and c-MeST vs. 68 % usual care, OR = 0.81, p = .606), three months (67 % usual care and c-MeST vs. 72 % usual care, OR = 0.64, p = .327) or six months (55 % usual care and c-MeST vs. 68 % usual care, OR = 0.56, p = .266). The usual care and c-MeST group did report lower depressive symptoms at one month (d = 0.42, p = .023) and six-months (d = 0.84, p = .001), but not three-months (d = 0.13, p > .05). c-MeST may reduce symptoms in youth with MDD when provided alongside other treatments. However, there are significant limitations to this inference, including high attrition in the study and a need for more data on the acceptability of the intervention. •Overgeneral memory appears to maintain depressive symptoms.•Computerized memory specificity training (c-MeST) improved memory specificity.•Depressive symptoms were reduced at one and six-month follow-up.•The effects occurred in addition to receiving other mental health support.•C-MeST may be a beneficial adjunct for youth with major depressive disorder.
  • Editor: Netherlands: Elsevier B.V
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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