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Design and patient characteristics of ESHOL study, a Catalonian prospective randomized study

Maduell, Francisco ; Moreso, Francesc ; Pons, Mercedes ; Ramos, Rosa ; Mora-Macià, Josep ; Foraster, Andreu ; Soler, Jordi ; Galceran, Josep M ; Martinez-Castelao, Alberto

Journal of nephrology, 2011-03, Vol.24 (2), p.196-202 [Periódico revisado por pares]

Italy

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Título:
Design and patient characteristics of ESHOL study, a Catalonian prospective randomized study
Autor: Maduell, Francisco ; Moreso, Francesc ; Pons, Mercedes ; Ramos, Rosa ; Mora-Macià, Josep ; Foraster, Andreu ; Soler, Jordi ; Galceran, Josep M ; Martinez-Castelao, Alberto
Assuntos: Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Hemodiafiltration ; Humans ; Kaplan-Meier Estimate ; Kidney Failure, Chronic - epidemiology ; Kidney Failure, Chronic - mortality ; Kidney Failure, Chronic - therapy ; Longitudinal Studies ; Male ; Middle Aged ; Prospective Studies ; Renal Dialysis ; Spain - epidemiology ; Survival Rate ; Treatment Outcome
É parte de: Journal of nephrology, 2011-03, Vol.24 (2), p.196-202
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-News-2
ObjectType-Feature-3
content type line 23
Descrição: Retrospective studies showed that online hemodiafiltration (OL-HDF) is associated with a risk reduction of mortality over standard hemodialysis (HD) in patients with end-stage renal disease. Until now, no information was available from prospective randomized clinical trials. A prospective, randomized, multicenter, open study was designed to be conducted in HD units from Catalonia (Spain). The aim of the study is to compare 3-year survival in prevalent end-stage renal disease patients randomized to OL-HDF or to continue on standard HD. The minimum sample size was calculated according to Catalonian mortality of patients on dialysis and assuming a risk reduction associated with OL-HDF of 35% (1-sided p<0.05 and a statistical power of 0.8) and a rate of dropout due to renal transplantation or loss to follow-up of 30%. From May 2007 to September 2008, 906 patients were included and randomized to OL-HDF (n=456) or standard HD (n=450). Demographics and analytical data at the time of randomization were not different between both groups of patients. Patients will be followed during a 3-year period. The present study will contribute to evaluating the benefit for patient survival of OL-HDF over standard HD.
Editor: Italy
Idioma: Inglês

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Design and patient characteristics of ESHOL study, a Catalonian prospective randomized study

Maduell, Francisco ; Moreso, Francesc ; Pons, Mercedes ; Ramos, Rosa ; Mora-Macià, Josep ; Foraster, Andreu ; Soler, Jordi ; Galceran, Josep M ; Martinez-Castelao, Alberto

Italy

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