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Evaluation of the antiplasmodial and leishmanicidal potential of Myrciaria dubia (Myrtaceae) extract

Correia, Vanessa Carolina de Sena ; Lima, Nathália Oliveira ; Oliveira, Flávio Augusto de Souza ; Santos, Ana Paula de Azevedo Dos ; Teles, Carolina Bioni Garcia ; Oliveira, Júnior, Waldesse Piragé de ; Pimenta, And Raphael Sanzio

Revista da Sociedade Brasileira de Medicina Tropical, 2016-09, Vol.49 (5), p.586-592 [Periódico revisado por pares]

Brazil: Sociedade Brasileira de Medicina Tropical

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Título:
Evaluation of the antiplasmodial and leishmanicidal potential of Myrciaria dubia (Myrtaceae) extract
Autor: Correia, Vanessa Carolina de Sena ; Lima, Nathália Oliveira ; Oliveira, Flávio Augusto de Souza ; Santos, Ana Paula de Azevedo Dos ; Teles, Carolina Bioni Garcia ; Oliveira, Júnior, Waldesse Piragé de ; Pimenta, And Raphael Sanzio
Assuntos: Antimalarials - isolation & purification ; Antimalarials - pharmacology ; Antimalarials - toxicity ; Antiprotozoal Agents - isolation & purification ; Antiprotozoal Agents - pharmacology ; Antiprotozoal Agents - toxicity ; Camu-camu ; Canguçu ; Colorimetry ; Environment ; Hep G2 Cells - drug effects ; Herbal medicine ; Humans ; Immunoenzyme Techniques ; Infections ; Inhibitory Concentration 50 ; Leishmania - classification ; Leishmania - drug effects ; Leishmania amazonensis ; Leishmania braziliensis ; Leishmania chagasi ; Leishmania spp ; Malaria ; Myrciaria ; Myrtaceae ; Myrtaceae - chemistry ; Parasitic Sensitivity Tests ; Plant Extracts - pharmacology ; Plant Extracts - toxicity ; Plasmodium falciparum ; Plasmodium falciparum - drug effects ; TROPICAL MEDICINE
É parte de: Revista da Sociedade Brasileira de Medicina Tropical, 2016-09, Vol.49 (5), p.586-592
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Malaria and leishmaniasis are prevalent in tropical regions, which have environmental characteristics that are highly favorable to protozoa and vectors of these diseases; the transmission of these infections in sub-tropical regions, although recognized, represents only a small fraction of cases. Plants are constantly being used in the search for and acquisition of new drugs, and many compounds derived from them have been used to combat various diseases. In this study, we evaluated the action of the dichloromethanolic extract of Myrciaria dubia leaves against the protozoa Plasmodium falciparum, Leishmania amazonensis, Leishmania braziliensis, and Leishmania chagasi through bioassays. The extract from M. dubia was tested for its anti-P. falciparum activity in an anti-histidine-rich protein II immunosorbent assay. The antileishmanial assays were performed using the resazurin method, while cytotoxicity against human hepatoma (HepG2) strain was determined using the colorimetric MTT [3-(4, 5-dimethyl-2- thiazolyl)-2, 5-diphenyl-2H tetrazolium bromide] method. The M. dubia extract presented a half-maximal inhibitory concentration equal to 2.35 (1.05)μg/mL for P. falciparum, 190.73 (6.41) μg/mL for L. amazonensis, and greater than equal to 200µg/mL for L. chagasi and L. braziliensis strains. The cytotoxic concentration for 50% of the cells was above 500μg/mL for HepG2, indicating no toxicity and greater selectivity against parasites. The results obtained indicate the presence of antiplasmodial and leishmanicidal bioactive compounds in the dichloromethanolic extracts of M. dubia leaves, and point towards future studies to elucidate the mechanism of action for each physiological effect.
Editor: Brazil: Sociedade Brasileira de Medicina Tropical
Idioma: Inglês;Português

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Evaluation of the antiplasmodial and leishmanicidal potential of Myrciaria dubia (Myrtaceae) extract

Correia, Vanessa Carolina de Sena ; Lima, Nathália Oliveira ; Oliveira, Flávio Augusto de Souza ; Santos, Ana Paula de Azevedo Dos ; Teles, Carolina Bioni Garcia ; Oliveira, Júnior, Waldesse Piragé de ; Pimenta, And Raphael Sanzio

Brazil: Sociedade Brasileira de Medicina Tropical

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