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Percutaneous biopsies of skeletal muscle and adipose tissue in individuals older than 70: methods and outcomes in the Study of Muscle, Mobility and Aging (SOMMA)

Zamora, Zeke ; Lui, Li-Yung ; Sparks, Lauren M. ; Justice, Jamie ; Lyles, Mary ; Gentle, Landon ; Gregory, Heather ; Yeo, Reichelle X. ; Kershaw, Erin E. ; Stefanovic-Racic, Maja ; Newman, Anne B. ; Kritchevsky, Stephen ; Toledo, Frederico G. S.

GeroScience, 2024-06, Vol.46 (3), p.3419-3428 [Periódico revisado por pares]

Cham: Springer International Publishing

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Título:
Percutaneous biopsies of skeletal muscle and adipose tissue in individuals older than 70: methods and outcomes in the Study of Muscle, Mobility and Aging (SOMMA)
Autor: Zamora, Zeke ; Lui, Li-Yung ; Sparks, Lauren M. ; Justice, Jamie ; Lyles, Mary ; Gentle, Landon ; Gregory, Heather ; Yeo, Reichelle X. ; Kershaw, Erin E. ; Stefanovic-Racic, Maja ; Newman, Anne B. ; Kritchevsky, Stephen ; Toledo, Frederico G. S.
Assuntos: Adipose Tissue ; Adverse events ; Aged ; Aging ; Biomedical and Life Sciences ; Biopsy ; Body fat ; Cell Biology ; Female ; Geriatrics/Gerontology ; Humans ; Life Sciences ; Male ; Mobility ; Molecular Medicine ; Muscle, Skeletal - pathology ; Older people ; Original Article ; Pain ; Safety ; Sarcopenia ; Sarcopenia - pathology ; Skeletal muscle ; Success
É parte de: GeroScience, 2024-06, Vol.46 (3), p.3419-3428
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Biopsies of muscle and adipose tissue (AT) are useful tools to gain insights into the aging processes in these tissues. However, they are invasive procedures and their risk/benefit profile in older adults can be altered by sarcopenia, frailty, poor healing, and multimorbidity. Their success rates, safety, and tolerability in a geriatric population have not been reported in detail. Investigators in the Study of Muscle, Mobility, and Aging (SOMMA) performed biopsies of muscle and AT in older adults and prospectively collected data on biopsy success rates, safety, and tolerability. We report here the methods and outcomes of these two procedures. In total, 861 participants (aged 70–94) underwent percutaneous biopsies of the Vastus lateralis muscle with a Bergstrom needle. A subset ( n = 241) also underwent percutaneous biopsies of the abdominal subcutaneous AT with the tumescent liposuction technique. Success rate was assessed by the percentage of biopsies yielding adequate specimens for analyses; tolerability by pain scores; and safety by frequency of adverse events. All data were prospectively collected. The overall muscle biopsy success rate was 97.1% and was modestly lower in women. The AT biopsy success rate was 95.9% and slightly lower in men. Minimal or no pain was reported in 68% of muscle biopsies and in 83% of AT biopsies. Adverse events occurred in 2.67% of muscle biopsies and 4.15% of AT biopsies. None was serious. In older adults, percutaneous muscle biopsies and abdominal subcutaneous AT biopsies have an excellent safety profile, often achieve adequate tissue yields for analyses, and are well tolerated.
Editor: Cham: Springer International Publishing
Idioma: Inglês

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Percutaneous biopsies of skeletal muscle and adipose tissue in individuals older than 70: methods and outcomes in the Study of Muscle, Mobility and Aging (SOMMA)

Zamora, Zeke ; Lui, Li-Yung ; Sparks, Lauren M. ; Justice, Jamie ; Lyles, Mary ; Gentle, Landon ; Gregory, Heather ; Yeo, Reichelle X. ; Kershaw, Erin E. ; Stefanovic-Racic, Maja ; Newman, Anne B. ; Kritchevsky, Stephen ; Toledo, Frederico G. S.

Cham: Springer International Publishing

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