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Euterpe Oleracea Mart. (Açaí) Reduces Oxidative Stress and Improves Energetic Metabolism in Myocardial Ischemia-Reperfusion Injury in Rats

Alegre, Patricia ; Mathias, Livia ; Lourenço, Maria Angelica ; Santos, Priscila Portugal Dos ; Gonçalves, Andrea ; Fernandes, Ana Angélica ; Gaiolla, Paula Schmidt Azevedo ; Minicucci, Marcos Ferreira ; Zornoff, Leonardo ; Paiva, Sergio Alberto Rupp ; Polegato, Bertha Furlan

Arquivos brasileiros de cardiologia, 2020-01, Vol.114 (1), p.78-86 [Periódico revisado por pares]

Brazil: Sociedade Brasileira de Cardiologia - SBC

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Título:
Euterpe Oleracea Mart. (Açaí) Reduces Oxidative Stress and Improves Energetic Metabolism in Myocardial Ischemia-Reperfusion Injury in Rats
Autor: Alegre, Patricia ; Mathias, Livia ; Lourenço, Maria Angelica ; Santos, Priscila Portugal Dos ; Gonçalves, Andrea ; Fernandes, Ana Angélica ; Gaiolla, Paula Schmidt Azevedo ; Minicucci, Marcos Ferreira ; Zornoff, Leonardo ; Paiva, Sergio Alberto Rupp ; Polegato, Bertha Furlan
Assuntos: Animals ; CARDIAC & CARDIOVASCULAR SYSTEMS ; Chemical Reactions ; Disease Models, Animal ; Energy Metabolism ; Energy Metabolism - drug effects ; Energy Metabolism - physiology ; Euterpe - chemistry ; Euterpe Olerácea ; Male ; Myocardial Ischemia ; Myocardial Reperfusion Injury ; Myocardial Reperfusion Injury - physiopathology ; Original ; Oxidative Stress ; Oxidative Stress - drug effects ; Oxidative Stress - physiology ; Plant Extracts - pharmacology ; Rats
É parte de: Arquivos brasileiros de cardiologia, 2020-01, Vol.114 (1), p.78-86
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Euterpe oleracea Mart. (açaí) is a fruit with high antioxidant capacity and could be an adjuvant strategy to attenuate ischemia-reperfusion injury. To evaluate the influence of açaí in global ischemia-reperfusion model in rats. Wistar rats were assigned to 2 groups: Control (C: receiving standard chow; n = 9) and Açaí (A: receiving standard chow supplemented with 5% açaí; n = 10). After six weeks, the animals were subjected to the global ischemia-reperfusion protocol and an isolated heart study to evaluate left ventricular function. Level of significance adopted: 5%. There was no difference between the groups in initial body weight, final body weight and daily feed intake. Group A presented lower lipid hydroperoxide myocardial concentration and higher catalase activity, superoxide dismutase and glutathione peroxidase than group C. We also observed increased myocardial activity of b-hydroxyacyl coenzyme-A dehydrogenase, pyruvate dehydrogenase, citrate synthase, complex I, complex II and ATP synthase in the A group as well as lower activity of the lactate dehydrogenase and phosphofructokinase enzymes. The systolic function was similar between the groups, and the A group presented poorer diastolic function than the C group. We did not observe any difference between the groups in relation to myocardial infarction area, total and phosphorylated NF-kB, total and acetylated FOXO1, SIRT1 and Nrf-2 protein expression. despite improving energy metabolism and attenuating oxidative stress, açai supplementation did not decrease the infarcted area or improve left ventricular function in the global ischemia-reperfusion model.
Editor: Brazil: Sociedade Brasileira de Cardiologia - SBC
Idioma: Inglês;Português

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Euterpe Oleracea Mart. (Açaí) Reduces Oxidative Stress and Improves Energetic Metabolism in Myocardial Ischemia-Reperfusion Injury in Rats

Alegre, Patricia ; Mathias, Livia ; Lourenço, Maria Angelica ; Santos, Priscila Portugal Dos ; Gonçalves, Andrea ; Fernandes, Ana Angélica ; Gaiolla, Paula Schmidt Azevedo ; Minicucci, Marcos Ferreira ; Zornoff, Leonardo ; Paiva, Sergio Alberto Rupp ; Polegato, Bertha Furlan

Brazil: Sociedade Brasileira de Cardiologia - SBC

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