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In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis: Trematocidal plant alcoholic extracts

Ferreira, Jorge F. S. ; Peaden, Paul ; Keiser, Jennifer

Parasitology research (1987), 2011-12, Vol.109 (6), p.1585-1592 [Periódico revisado por pares]

Berlin/Heidelberg: Springer-Verlag

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Título:
In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis: Trematocidal plant alcoholic extracts
Autor: Ferreira, Jorge F. S. ; Peaden, Paul ; Keiser, Jennifer
Assuntos: Animals ; Anthelmintics - pharmacology ; Artemisia absinthium - chemistry ; Artemisia annua - chemistry ; Asimina - chemistry ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Chromatography ; Echinostoma - drug effects ; Fasciola hepatica - drug effects ; Fumaria ; Fundamental and applied biological sciences. Psychology ; General aspects ; General aspects and techniques. Study of several systematic groups. Models ; Humans ; Immunology ; International economic relations ; Invertebrates ; Livestock ; Medical Microbiology ; Microbiology ; Original Paper ; Plant Extracts - pharmacology ; Schistosoma mansoni - drug effects ; Trematoda - drug effects ; Veterinary supplies industry
É parte de: Parasitology research (1987), 2011-12, Vol.109 (6), p.1585-1592
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Trematode infections negatively affect human and livestock health, and threaten global food safety. The only approved human anthelmintics for trematodiasis are triclabendazole and praziquantel with no alternative drugs in sight. We tested six crude plant extracts against adult Schistosoma mansoni , Fasciola hepatica , and Echinostoma caproni in vitro. Mortality was best achieved by ethanolic extracts of Artemisia annua (sweet Annie), Asimina triloba (paw-paw), and Artemisia absinthium (wormwood) which, at 2 mg/mL, killed S. mansoni and E. caproni in 20 h or less (except for wormwood), F. hepatica between 16 and 23 h (sweet Annie), or 40 h (paw-paw). Some extracts were active at 0.2 mg/mL and 20 μg/mL, although more time was required to kill trematodes. However, aqueous A. annua and methanol extracts of Fumaria officinalis had no activity. Chromatographic analysis of the three best extracts established that A. annua and A. triloba extracts contained bioactive artemisinin and acetogenins (asimicin and bullatacin), respectively. The anthelmintic activity of our extracts at such low doses indicates that their anthelmintic activity deserves further testing as natural alternative controls for parasites of both animals and humans. Our results also support recent evidence that synergistic effects of multiple bioactive compounds present in crude plant extracts is worth exploring.
Editor: Berlin/Heidelberg: Springer-Verlag
Idioma: Inglês

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In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis: Trematocidal plant alcoholic extracts

Ferreira, Jorge F. S. ; Peaden, Paul ; Keiser, Jennifer

Berlin/Heidelberg: Springer-Verlag

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