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Genome-wide association study of blood pressure and hypertension

Hwang, Shih-Jen ; Vasan, Ramachandran S ; O'Donnell, Christopher J ; Levy, Daniel ; Mattace-Raso, Francesco U S ; Morrison, Alanna C ; Scharpf, Robert B ; Psaty, Bruce M ; Rice, Kenneth ; Harris, Tamara B ; Ganesh, Santhi K ; Glazer, Nicole L ; Aspelund, Thor ; Larson, Martin G ; Witteman, Jacqueline C M ; Gudnason, Vilmundur ; van Duijn, Cornelia M ; Rivadeneira, Fernando ; Boerwinkle, Eric ; Mitchell, Gary F ; Heiss, Gerardo ; Taylor, Kent ; Chakravarti, Aravinda ; Ehret, Georg B ; Dehghan, Abbas ; Johnson, Andrew D ; Lumley, Thomas ; Eiriksdottir, Gudny ; Köttgen, Anna ; Guo, Xiuqing ; Fox, Caroline S ; Sijbrands, Eric J G ; Bis, Joshua ; Hofman, Albert ; Verwoert, Germaine C ; Uitterlinden, André G ; Launer, Lenore J ; Benjamin, Emelia J ; Aulchenko, Yurii ; Arking, Dan E ; Coresh, Josef ; Rotter, Jerome I ; Wang, Thomas J ; Smith, Albert V

Nature genetics, 2009-06, Vol.41 (6), p.677-687 [Periódico revisado por pares]

New York, NY: Nature Publishing Group

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Título:
Genome-wide association study of blood pressure and hypertension
Autor: Hwang, Shih-Jen ; Vasan, Ramachandran S ; O'Donnell, Christopher J ; Levy, Daniel ; Mattace-Raso, Francesco U S ; Morrison, Alanna C ; Scharpf, Robert B ; Psaty, Bruce M ; Rice, Kenneth ; Harris, Tamara B ; Ganesh, Santhi K ; Glazer, Nicole L ; Aspelund, Thor ; Larson, Martin G ; Witteman, Jacqueline C M ; Gudnason, Vilmundur ; van Duijn, Cornelia M ; Rivadeneira, Fernando ; Boerwinkle, Eric ; Mitchell, Gary F ; Heiss, Gerardo ; Taylor, Kent ; Chakravarti, Aravinda ; Ehret, Georg B ; Dehghan, Abbas ; Johnson, Andrew D ; Lumley, Thomas ; Eiriksdottir, Gudny ; Köttgen, Anna ; Guo, Xiuqing ; Fox, Caroline S ; Sijbrands, Eric J G ; Bis, Joshua ; Hofman, Albert ; Verwoert, Germaine C ; Uitterlinden, André G ; Launer, Lenore J ; Benjamin, Emelia J ; Aulchenko, Yurii ; Arking, Dan E ; Coresh, Josef ; Rotter, Jerome I ; Wang, Thomas J ; Smith, Albert V
Assuntos: Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood pressure ; Blood Pressure - genetics ; Cardiology. Vascular system ; Cardiovascular diseases ; Care and treatment ; Cell Line ; Chromosome Mapping ; Chromosomes, Human - genetics ; Complications and side effects ; Data analysis ; Diastole - genetics ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Genetic aspects ; Genetic Association Studies ; Genetics of eukaryotes. Biological and molecular evolution ; Genome-Wide Association Study ; Health aspects ; Humans ; Hypertension ; Hypertension - epidemiology ; Hypertension - genetics ; Liver - physiology ; Liver - physiopathology ; Lymphocytes - physiology ; Medical research ; Medical sciences ; Meta-analysis ; Meta-Analysis as Topic ; Odds Ratio ; Phenotype ; Prevalence ; Prevention ; Risk Assessment ; Risk factors ; Sample size ; Studies ; Systole - genetics
É parte de: Nature genetics, 2009-06, Vol.41 (6), p.677-687
Notas: ObjectType-Article-1
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These authors contributed equally
Descrição: Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated with interindividual blood pressure variation have been identified and replicated. Here we report results of a genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium (n = 29,136), identifying 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10(-7). The top ten loci for SBP and DBP were incorporated into a risk score; mean BP and prevalence of hypertension increased in relation to the number of risk alleles carried. When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 × 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1). Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension.
Editor: New York, NY: Nature Publishing Group
Idioma: Inglês

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Genome-wide association study of blood pressure and hypertension

New York, NY: Nature Publishing Group

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