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Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis

OLOFSSON, S.‐O. ; BORÈN, J.

Journal of internal medicine, 2005-11, Vol.258 (5), p.395-410 [Periódico revisado por pares]

Oxford, UK: Blackwell Science Ltd

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Título:
Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis
Autor: OLOFSSON, S.‐O. ; BORÈN, J.
Assuntos: Apolipoprotein B-100 ; Apolipoprotein B-48 ; apolipoproteins B ; Apolipoproteins B - chemistry ; Apolipoproteins B - metabolism ; Apolipoproteins B/chemistry/metabolism ; Arteriosclerosis - etiology ; Arteriosclerosis - metabolism ; Arteriosclerosis/etiology/metabolism ; atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Biological ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; General aspects ; Glycosaminoglycans - metabolism ; Humans ; Hyperlipidemias - metabolism ; Hyperlipidemias - prevention & control ; Hyperlipidemias/metabolism/prevention & control ; Lipoproteins ; Lipoproteins, VLDL - chemistry ; Lipoproteins, VLDL - metabolism ; MEDICAL AND HEALTH SCIENCES ; Medical sciences ; MEDICIN OCH HÄLSOVETENSKAP ; Models, Biological ; proteoglycans ; Proteoglycans - metabolism ; Risk Factors ; Triglycerides - metabolism ; very low‐density lipoprotein assembly ; very low‐density lipoproteins ; VLDL/chemistry/metabolism
É parte de: Journal of internal medicine, 2005-11, Vol.258 (5), p.395-410
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: . Apolipoprotein (apo) B exists in two forms apoB100 and apoB48. ApoB100 is present on very low‐density lipoproteins (VLDL), intermediate density lipoproteins (IDL) and LDL. ApoB100 assembles VLDL particles in the liver. This process starts by the formation of a pre‐VLDL, which is retained in the cell unless converted to the triglyceride‐poor VLDL2. VLDL2 is secreted or converted to VLDL1 by a bulk lipidation in the Golgi apparatus. ApoB100 has a central role in the development of atherosclerosis. Two proteoglycan‐binding sequences in apoB100 have been identified, which are important for retaining the lipoprotein in the intima of the artery. Retention is essential for the development of the atherosclerotic lesion.
Editor: Oxford, UK: Blackwell Science Ltd
Idioma: Inglês

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Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis

OLOFSSON, S.‐O. ; BORÈN, J.

Oxford, UK: Blackwell Science Ltd

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