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A Comprehensive Immunologic Portrait of Triple-Negative Breast Cancer

Liu, Zhixian ; Li, Mengyuan ; Jiang, Zehang ; Wang, Xiaosheng

Translational oncology, 2018-04, Vol.11 (2), p.311-329 [Periódico revisado por pares]

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Título:
A Comprehensive Immunologic Portrait of Triple-Negative Breast Cancer
Autor: Liu, Zhixian ; Li, Mengyuan ; Jiang, Zehang ; Wang, Xiaosheng
Assuntos: Original article
É parte de: Translational oncology, 2018-04, Vol.11 (2), p.311-329
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Triple-negative breast cancer (TNBC) is a high-risk malignancy due to its high capacity for invasion and lack of targeted therapy. Immunotherapy continues to demonstrate efficacy in a variety of cancers, and thus may be a promising strategy for TNBC given the limited therapeutic options currently available for TNBC. In this study, we performed an exhaustive analysis of immunogenic signatures in TNBC based on 2 large-scale breast cancer (BC) genomic data. We compared enrichment levels of 26 immune cell activities and pathways among TNBC, non-TNBC, and normal tissue, and within TNBCs of different genotypic or phenotypic features. We found that almost all analyzed immune activities and pathways had significantly higher enrichment levels in TNBC than non-TNBC. Elevated enrichment of these immune activities and pathways was likely to be associated with better survival prognosis in TNBC. This study demonstrated that TNBC likely exhibits the strongest immunogenicity among BC subtypes, and thus warrants the immunotherapeutic option for TNBC.
Editor: United States: Elsevier Inc
Idioma: Inglês

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