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Induction of insulin resistance by high‐sucrose feeding does not raise mean arterial blood pressure but impairs haemodynamic responses to insulin in rats

Santuré, Marta ; Pitre, Maryse ; Marette, André ; Deshaies, Yves ; Lemieux, Christian ; Lariviére, Richard ; Nadeau, André ; Bachelard, Hélène

British journal of pharmacology, 2002-09, Vol.137 (2), p.185-196 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
Induction of insulin resistance by high‐sucrose feeding does not raise mean arterial blood pressure but impairs haemodynamic responses to insulin in rats
Autor: Santuré, Marta ; Pitre, Maryse ; Marette, André ; Deshaies, Yves ; Lemieux, Christian ; Lariviére, Richard ; Nadeau, André ; Bachelard, Hélène
Assuntos: Animals ; Associated diseases and complications ; Biological and medical sciences ; blood pressure ; Blood Pressure - drug effects ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; endothelin ; Endothelin-1 - analysis ; glucose transport ; Hemodynamics - drug effects ; Insulin - pharmacology ; Insulin Resistance ; insulin vascular effects ; Male ; Medical sciences ; Mesenteric Arteries - chemistry ; Muscle, Skeletal - metabolism ; nitric oxide synthase ; Nitric Oxide Synthase - analysis ; Rats ; Rats, Sprague-Dawley ; regional blood flow ; Sucrose - administration & dosage ; sucrose diet
É parte de: British journal of pharmacology, 2002-09, Vol.137 (2), p.185-196
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: This study was undertaken to further investigate the effects of a sucrose‐enriched diet on vascular function and insulin sensitivity in rats. Male Sprague‐Dawley rats were randomized to receive a sucrose‐ or regular rat chow‐diet for 4 weeks. A first group of sucrose‐ and chow‐fed rats was instrumented with pulsed Doppler flow probes and intravascular catheters to determine blood pressure, heart rate, regional blood flows and insulin sensitivity in conscious rats. Insulin sensitivity was assessed by the euglycemic hyperinsulinemic clamp technique. Glucose transport activity was examined in isolated muscles by using the glucose analogue [3H]‐2‐deoxy‐D‐glucose. A second group of sucrose‐ and chow‐fed rats was used to obtain information regarding nitric oxide synthase (NOS) isozymes protein expression in muscles, and determine endothelin content in vascular tissues isolated from both dietary groups. Sucrose feeding was found to induce insulin resistance, but had no effect on resting blood pressure, heart rate, or regional haemodynamics. This insulin resistance was accompanied by alteration in the vascular responses to insulin. Insulin‐mediated skeletal muscle vasodilation was impaired, whereas the mesenteric vasoconstrictor response was potentiated in sucrose‐fed rats. A reduction in eNOS protein content in muscle and an increase in vascular endothelin peptide were noted in these animals. Moreover, a reduction in insulin‐simulated glucose transport activity was also noted in muscles isolated from sucrose‐fed rats. Together these data suggest that a cluster of metabolic and haemodynamic abnormalities occur in response to the intake of simple sugars in rats. British Journal of Pharmacology (2002) 137, 185–196. doi:10.1038/sj.bjp.0704864
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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Induction of insulin resistance by high‐sucrose feeding does not raise mean arterial blood pressure but impairs haemodynamic responses to insulin in rats

Santuré, Marta ; Pitre, Maryse ; Marette, André ; Deshaies, Yves ; Lemieux, Christian ; Lariviére, Richard ; Nadeau, André ; Bachelard, Hélène

Oxford, UK: Blackwell Publishing Ltd

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