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Chemical requirements of vasopressins for barrel rotation convulsions and reversal by oxytocin

Abood, L. G. ; Knapp, R. ; Mitchell, T. ; Booth, H. ; Schwab, L.

Journal of neuroscience research, 1980, Vol.5 (3), p.191-199 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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Título:
Chemical requirements of vasopressins for barrel rotation convulsions and reversal by oxytocin
Autor: Abood, L. G. ; Knapp, R. ; Mitchell, T. ; Booth, H. ; Schwab, L.
Assuntos: Animals ; convulsions ; Dose-Response Relationship, Drug ; hippocampus ; Hippocampus - physiopathology ; Injections, Intraventricular ; Myoclonus - chemically induced ; neuropeptides ; oxytocin ; Oxytocin - therapeutic use ; Peptides - administration & dosage ; Rats ; Seizures - chemically induced ; Seizures - physiopathology ; Seizures - prevention & control ; vasopressin ; Vasopressins - administration & dosage ; Vasopressins - antagonists & inhibitors
É parte de: Journal of neuroscience research, 1980, Vol.5 (3), p.191-199
Notas: ark:/67375/WNG-7SSL5M36-C
ArticleID:JNR490050304
istex:37D7E568A44BFB5924A0D00493DD6A6BD04D7E7A
Descrição: When vasopressin is administred into the lateral ventricles of rats it produces severe convulsive activity characterized by a rapid barrel rotation. Electrical recordings from the dorsal hippocampus indicate marked elevations in the amplitude and frequency at doses of 5 μl of 2 × 10−5 M vasopressin. No significant behavioral effects were noted with oxytocin, somatostatin, β‐melanophore‐stimulating hormone, adrenocorticotropin, or leu‐enkephalin. Pretreatment of the rats with intraventricularly administered oxytocin, β‐MSH, or systemically administered Dilantin prevented the vasopressin‐induced seizures. With the use of chemical and enzymic modification procedures, the essential fragment and amino acids of vasopressin needed for the activity were determined. It was concluded that although the peptide could be acting by vasoconstricting blood arterioles and capillaries in the brain, it may also be exerting a direct excitatory action on neurons.
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

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Chemical requirements of vasopressins for barrel rotation convulsions and reversal by oxytocin

Abood, L. G. ; Knapp, R. ; Mitchell, T. ; Booth, H. ; Schwab, L.

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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