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Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals
Jullesson, David ; David, Florian ; Pfleger, Brian ; Nielsen, Jens
Biotechnology advances, 2015-11, Vol.33 (7), p.1395-1402
[Peer Reviewed Journal]
England: Elsevier Inc
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Title:
Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals
Author:
Jullesson, David
;
David, Florian
;
Pfleger, Brian
;
Nielsen, Jens
Subjects:
Biology
;
Cell factories
;
Escherichia coli
;
Factories
;
Fine chemicals
;
Industrial engineering
;
Industrial Microbiology
;
Industrial plants
;
Industrial production
;
Manufacturing engineering
;
Mathematical models
;
Metabolic Engineering
;
Saccharomyces cerevisiae
;
Strain
;
Synthetic Biology
Is Part Of:
Biotechnology advances, 2015-11, Vol.33 (7), p.1395-1402
Notes:
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
Description:
Industrial bio-processes for fine chemical production are increasingly relying on cell factories developed through metabolic engineering and synthetic biology. The use of high throughput techniques and automation for the design of cell factories, and especially platform strains, has played an important role in the transition from laboratory research to industrial production. Model organisms such as Saccharomyces cerevisiae and Escherichia coli remain widely used host strains for industrial production due to their robust and desirable traits. This review describes some of the bio-based fine chemicals that have reached the market, key metabolic engineering tools that have allowed this to happen and some of the companies that are currently utilizing these technologies for developing industrial production processes.
Publisher:
England: Elsevier Inc
Language:
English
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