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18FDG conjugated magnetic nanoparticle probes: synthesis and in vitro investigations on MCF-7 breast cancer cells

Ozkaya, Feriha ; Unak, Perihan ; Medine, E. Ilker ; Sakarya, Serhan ; Unak, Gülcan ; Timur, Suna

Journal of radioanalytical and nuclear chemistry, 2013-03, Vol.295 (3), p.1789-1796 [Periódico revisado por pares]

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Título:
18FDG conjugated magnetic nanoparticle probes: synthesis and in vitro investigations on MCF-7 breast cancer cells
Autor: Ozkaya, Feriha ; Unak, Perihan ; Medine, E. Ilker ; Sakarya, Serhan ; Unak, Gülcan ; Timur, Suna
Assuntos: Breast ; Cancer ; Chemistry ; Chemistry and Materials Science ; Diagnostic Radiology ; Hadrons ; Heavy Ions ; Human ; Imaging ; Inorganic Chemistry ; Iron oxides ; Nanoparticles ; Nanostructure ; Nuclear Chemistry ; Nuclear Physics ; Physical Chemistry
É parte de: Journal of radioanalytical and nuclear chemistry, 2013-03, Vol.295 (3), p.1789-1796
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: 18 FDG conjugated magnetic iron oxide nanoparticles (MNPs) were synthesized as PET-MR hybrid imaging agent. Synthesized and characterized NPs were then applied to MCF-7 human breast cancer cells. 18 FDG conjugated MNPs exhibited the cell incorporation ratio up to 30 %. As well as the characterization studies, apoptotic effects were observed depending on the cellular incorporations by the time. In conclusion, synthesized structures could have a potential as hybrid imaging agent in PET-MR imaging systems besides apoptotic effect on cancer cells.
Editor: Dordrecht: Springer Netherlands
Idioma: Inglês

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