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Predictive relevance of PD-L1 expression combined with CD8+ TIL density in stage III non-small cell lung cancer patients receiving concurrent chemoradiotherapy

Tokito, Takaaki ; Azuma, Koichi ; Kawahara, Akihiko ; Ishii, Hidenobu ; Yamada, Kazuhiko ; Matsuo, Norikazu ; Kinoshita, Takashi ; Mizukami, Naohisa ; Ono, Hirofumi ; Kage, Masayoshi ; Hoshino, Tomoaki

European journal of cancer (1990), 2016-03, Vol.55, p.7-14 [Periódico revisado por pares]

England: Elsevier Ltd

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Título:
Predictive relevance of PD-L1 expression combined with CD8+ TIL density in stage III non-small cell lung cancer patients receiving concurrent chemoradiotherapy
Autor: Tokito, Takaaki ; Azuma, Koichi ; Kawahara, Akihiko ; Ishii, Hidenobu ; Yamada, Kazuhiko ; Matsuo, Norikazu ; Kinoshita, Takashi ; Mizukami, Naohisa ; Ono, Hirofumi ; Kage, Masayoshi ; Hoshino, Tomoaki
Assuntos: Adult ; Aged ; Aged, 80 and over ; B7-H1 Antigen - analysis ; Biomarkers, Tumor - analysis ; Carcinoma, Non-Small-Cell Lung - chemistry ; Carcinoma, Non-Small-Cell Lung - immunology ; Carcinoma, Non-Small-Cell Lung - metabolism ; Carcinoma, Non-Small-Cell Lung - mortality ; Carcinoma, Non-Small-Cell Lung - therapy ; CD8+ TIL ; CD8-Positive T-Lymphocytes - immunology ; Chemoradiotherapy ; Disease-Free Survival ; Female ; Hematology, Oncology and Palliative Medicine ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Lung Neoplasms - chemistry ; Lung Neoplasms - immunology ; Lung Neoplasms - metabolism ; Lung Neoplasms - mortality ; Lung Neoplasms - therapy ; Lymphocyte Count ; Lymphocytes, Tumor-Infiltrating - immunology ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; non-small cell lung cancer ; PD-L1 ; Predictive Value of Tests ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome
É parte de: European journal of cancer (1990), 2016-03, Vol.55, p.7-14
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Abstract Background Expression of programmed cell death-ligand 1 (PD-L1) is known to be a mechanism whereby cancer can escape immune surveillance, but little is known about factors predictive of efficacy in patients with locally advanced non-small cell lung cancer (NSCLC). We investigated the predictive relevance of PD-L1 expression and CD8+ tumour-infiltrating lymphocytes (TILs) density in patients with locally advanced NSCLC receiving concurrent chemoradiotherapy (CCRT). Methods We retrospectively reviewed 74 consecutive patients with stage III NSCLC who had received CCRT. PD-L1 expression and CD8+ TIL density were evaluated by immunohistochemical analysis. Results Univariate and multivariate analyses demonstrated that CD8+ TIL density was an independent and significant predictive factor for progression-free survival (PFS) and OS, whereas PD-L1 expression was not correlated with PFS and OS. Sub-analysis revealed that the PD-L1+/CD8 low group had the shortest PFS (8.6 months, p = 0.02) and OS (13.9 months, p = 0.11), and that the PD-L1-/CD8 high group had the longest prognosis (median PFS and OS were not reached) by Kaplan-Meier curves of the four sub-groups. Conclusions Among stage III NSCLC patients who received CCRT, there was a trend for poor survival in those who expressed PD-L1. Our analysis indicated that a combination of lack of PD-L1 expression and CD8+ TIL density was significantly associated with favourable survival in these patients. It is proposed that PD-L1 expression in combination with CD8+ TIL density could be a useful predictive biomarker in patients with stage III NSCLC.
Editor: England: Elsevier Ltd
Idioma: Inglês

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Predictive relevance of PD-L1 expression combined with CD8+ TIL density in stage III non-small cell lung cancer patients receiving concurrent chemoradiotherapy

Tokito, Takaaki ; Azuma, Koichi ; Kawahara, Akihiko ; Ishii, Hidenobu ; Yamada, Kazuhiko ; Matsuo, Norikazu ; Kinoshita, Takashi ; Mizukami, Naohisa ; Ono, Hirofumi ; Kage, Masayoshi ; Hoshino, Tomoaki

England: Elsevier Ltd

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