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Post-mortem findings in Spanish patients with COVID-19; a special focus on superinfections

Ruiz Cáceres, Inmaculada ; Hermida Romero, Teresa ; Guerra Merino, Isabel ; Portu Zapirain, Joseba ; Pérez Mies, Belén ; Sánchez Conde, Matilde ; Alonso Riaño, Marina ; Rubio Campillo, Rafael ; Fortés Alen, Jose ; Vidal González, Ánxela ; Salas Antón, Clara ; Múñez, Elena ; Sánchez Sánchez, Rafael ; Corona Mata, Diana ; Aldecoa Ansorregui, Iban ; Miró, José M ; Beloqui Pérez de Obanos, Raquel ; Ibero, Carlos ; Gómez Román, Javier ; Fariñas, María Carmen ; Tabuyo Bello, Teresa ; Alava, Enrique de ; Cisneros, José Miguel ; Matias-Guiu, Xavier ; Rivero, Antonio ; NecroCOVID Study Group

Frontiers Media SA 2023-07

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Post-mortem findings in Spanish patients with COVID-19; a special focus on superinfections
Autor: Ruiz Cáceres, Inmaculada ; Hermida Romero, Teresa ; Guerra Merino, Isabel ; Portu Zapirain, Joseba ; Pérez Mies, Belén ; Sánchez Conde, Matilde ; Alonso Riaño, Marina ; Rubio Campillo, Rafael ; Fortés Alen, Jose ; Vidal González, Ánxela ; Salas Antón, Clara ; Múñez, Elena ; Sánchez Sánchez, Rafael ; Corona Mata, Diana ; Aldecoa Ansorregui, Iban ; Miró, José M ; Beloqui Pérez de Obanos, Raquel ; Ibero, Carlos ; Gómez Román, Javier ; Fariñas, María Carmen ; Tabuyo Bello, Teresa ; Alava, Enrique de ; Cisneros, José Miguel ; Matias-Guiu, Xavier ; Rivero, Antonio ; NecroCOVID Study Group
Assuntos: COVID-19 ; Fisiologia patològica ; Pathological physiology
Notas: https://doi.org/10.3389/fmed.2023.1151843
37484846
http://hdl.handle.net/2445/204400
2296-858X
Reproducció del document publicat a: https://doi.org/10.3389/fmed.2023.1151843
Frontiers in Medicine, 2023, vol. 10
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Descrição: IntroductionWhole-body autopsies may be crucial to understand coronavirus disease 2019 (COVID-19) pathophysiology. We aimed to analyze pathological findings in a large series of full-body autopsies, with a special focus on superinfections. MethodsThis was a prospective multicenter study that included 70 COVID-19 autopsies performed between April 2020 and February 2021. Epidemiological, clinical and pathological information was collected using a standardized case report form. ResultsMedian (IQR) age was 70 (range 63.75-74.25) years and 76% of cases were males. Most patients (90%,) had at least one comorbidity prior to COVID-19 diagnosis, with vascular risk factors being the most frequent. Infectious complications were developed by 65.71% of the patients during their follow-up. Mechanical ventilation was required in most patients (75.71%) and was mainly invasive. In multivariate analyses, length of hospital stay and invasive mechanical ventilation were significantly associated with infections (p = 0.036 and p = 0.013, respectively). Necropsy findings revealed diffuse alveolar damage in the lungs, left ventricular hypertrophy in the heart, liver steatosis and pre-infection arteriosclerosis in the heart and kidneys. ConclusionOur study confirms the main necropsy histopathological findings attributed to COVID-19 in a large patient series, while underlining the importance of both comorbid conditions and superinfections in the pathology.
Editor: Frontiers Media SA
Data de criação/publicação: 2023-07
Idioma: Inglês

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Post-mortem findings in Spanish patients with COVID-19; a special focus on superinfections

Frontiers Media SA 2023-07

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