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Targeting Skin Dendritic Cells to Improve Intradermal Vaccination

Romani, N. ; Flacher, V. ; Tripp, C. H. ; Sparber, F. ; Ebner, S. ; Stoitzner, P.

Current topics in microbiology and immunology, 2012, Vol.351, p.113-138 [Periódico revisado por pares]

Berlin, Heidelberg: Springer Berlin Heidelberg

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Título:
Targeting Skin Dendritic Cells to Improve Intradermal Vaccination
Autor: Romani, N. ; Flacher, V. ; Tripp, C. H. ; Sparber, F. ; Ebner, S. ; Stoitzner, P.
Assuntos: Adaptive Immunity ; Animals ; Antigens, CD - analysis ; Antigens, CD - biosynthesis ; Antigens, CD - immunology ; B-Lymphocytes - immunology ; Bacterial Infections - immunology ; Bacterial Infections - prevention & control ; CD40 Ligation ; Cell Lineage - immunology ; Cytokines - analysis ; Cytokines - biosynthesis ; Dendritic Cell ; Dendritic Cell Subset ; Dermis - cytology ; Dermis - immunology ; Drug Delivery Systems - methods ; Endocytic Receptor ; Humans ; Immunity, Innate ; Immunology ; Injections, Intradermal ; Langerhans Cells - cytology ; Langerhans Cells - immunology ; Lectins, C-Type - analysis ; Lectins, C-Type - biosynthesis ; Life Sciences ; Lymphocyte Activation ; Macrophage Mannose Receptor ; Mannose-Binding Lectins - analysis ; Mannose-Binding Lectins - biosynthesis ; Mice ; T-Lymphocytes, Cytotoxic - immunology ; Vaccination - methods ; Vaccines - administration & dosage ; Vaccines - immunology ; Virus Diseases - immunology ; Virus Diseases - prevention & control
É parte de: Current topics in microbiology and immunology, 2012, Vol.351, p.113-138
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
PMCID: PMC4285659
Descrição: Vaccinations in medicine are typically administered into the muscle beneath the skin or into the subcutaneous fat. As a consequence, the vaccine is immunologically processed by antigen-presenting cells of the skin or the muscle. Recent evidence suggests that the clinically seldom used intradermal route is effective and possibly even superior to the conventional subcutaneous or intramuscular route. Several types of professional antigen-presenting cells inhabit the healthy skin. Epidermal Langerhans cells (CD207/langerin+), dermal langerinneg, and dermal langerin+ dendritic cells (DC) have been described, the latter subset so far only in mouse skin. In human skin langerinneg dermal DC can be further classified based on their reciprocal expression of CD1a and CD14. The relative contributions of these subsets to the generation of immunity or tolerance are still unclear. Yet, specializations of these different populations have become apparent. Langerhans cells in human skin appear to be specialized for induction of cytotoxic T lymphocytes; human CD14+ dermal DC can promote antibody production by B cells. It is currently attempted to rationally devise and improve vaccines by harnessing such specific properties of skin DC. This could be achieved by specifically targeting functionally diverse skin DC subsets. We discuss here advances in our knowledge on the immunological properties of skin DC and strategies to significantly improve the outcome of vaccinations by applying this knowledge.
Títulos relacionados: Current Topics in Microbiology and Immunology
Editor: Berlin, Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

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Targeting Skin Dendritic Cells to Improve Intradermal Vaccination

Romani, N. ; Flacher, V. ; Tripp, C. H. ; Sparber, F. ; Ebner, S. ; Stoitzner, P.

Berlin, Heidelberg: Springer Berlin Heidelberg

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