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Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

Davis, James P ; Huyghe, Jeroen R ; Locke, Adam E ; Jackson, Anne U ; Sim, Xueling ; Stringham, Heather M ; Teslovich, Tanya M ; Welch, Ryan P ; Fuchsberger, Christian ; Narisu, Narisu ; Chines, Peter S ; Kangas, Antti J ; Soininen, Pasi ; Ala-Korpela, Mika ; Kuusisto, Johanna ; Collins, Francis S ; Laakso, Markku ; Boehnke, Michael ; Mohlke, Karen L Loos, Ruth J. F.

PLoS genetics, 2017-10, Vol.13 (10), p.e1007079-e1007079 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study
Autor: Davis, James P ; Huyghe, Jeroen R ; Locke, Adam E ; Jackson, Anne U ; Sim, Xueling ; Stringham, Heather M ; Teslovich, Tanya M ; Welch, Ryan P ; Fuchsberger, Christian ; Narisu, Narisu ; Chines, Peter S ; Kangas, Antti J ; Soininen, Pasi ; Ala-Korpela, Mika ; Kuusisto, Johanna ; Collins, Francis S ; Laakso, Markku ; Boehnke, Michael ; Mohlke, Karen L
Loos, Ruth J. F.
Assuntos: Biology and Life Sciences ; Blood lipoproteins ; Cardiovascular disease ; Cardiovascular diseases ; Cholesterol, HDL - genetics ; Clinical medicine ; Consortia ; Diabetes ; Dyslipidemia ; Epidemiology ; Etiology ; European Continental Ancestry Group - genetics ; Exome - genetics ; Finland ; Funding ; Gene frequency ; Gene Frequency - genetics ; Genetic aspects ; Genetic diversity ; Genetic variance ; Genetics ; Genome-Wide Association Study - methods ; Genomes ; Genotype ; Genotypes ; Health care ; Heart diseases ; Hospitals ; Humans ; Internal medicine ; Kinases ; Laboratories ; Lipid Metabolism - genetics ; Lipids ; Lipids - genetics ; Lipoproteins ; Lipoproteins - genetics ; Male ; Mens health ; Metabolic disorders ; Metabolism ; Middle Aged ; NMR ; Nuclear magnetic resonance ; Pharmacy ; Physiological aspects ; Polymorphism, Single Nucleotide - genetics ; Preventive medicine ; Principal Component Analysis - methods ; Proteolipids ; Software ; Studies ; Supervision ; Triglycerides ; Triglycerides - genetics
É parte de: PLoS genetics, 2017-10, Vol.13 (10), p.e1007079-e1007079
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ML, MB, and KLM also contributed equally to this work.
I have read the journal's policy and the authors of this manuscript have the following competing interests: AJK and PS are shareholders of Brainshake Ltd., a company offering NMR‑based metabolite profiling. AJK and PS report employment relation for Brainshake Ltd.
Descrição: Lipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based association tests between 15.1M variants from genome-wide and exome array and imputed genotypes and 72 lipid and lipoprotein traits in 8,372 Finns. After accounting for 885 variants at 157 previously identified lipid loci, we identified five novel signals near established loci at HIF3A, ADAMTS3, PLTP, LCAT, and LIPG. Four of the signals were identified with a low-frequency (0.005
Editor: United States: Public Library of Science
Idioma: Inglês

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Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

United States: Public Library of Science

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