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Tumour Necrosis Factor-alpha and Nuclear Factor-kappa B Gene Variants in Sepsis

Acar, Leyla ; Atalan, Nazan ; Karagedik, E Hande ; Ergen, Arzu Koçak,Zafer

Balkan medical journal, 2018-01, Vol.35 (1), p.30-35 [Periódico revisado por pares]

Turkey: Galenos Yayinevi Tic. Ltd

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Título:
Tumour Necrosis Factor-alpha and Nuclear Factor-kappa B Gene Variants in Sepsis
Autor: Acar, Leyla ; Atalan, Nazan ; Karagedik, E Hande ; Ergen, Arzu
Koçak,Zafer
Assuntos: Aged ; Care and treatment ; Case-Control Studies ; Cytokines ; Development and progression ; Enzymes ; Female ; Gene expression ; Genes ; Genetic aspects ; Genetic polymorphisms ; Genotype & phenotype ; Health aspects ; Humans ; Inflammatory diseases ; Lymphoma ; Male ; Middle Aged ; Mortality ; Necrosis ; NF-kappa B ; NF-kappa B - blood ; NF-kappa B - genetics ; Original ; Polymorphism ; Polymorphism, Restriction Fragment Length ; Proteins ; Sepsis ; Sepsis - blood ; Sepsis - genetics ; Studies ; Tıp ; TNF inhibitors ; Transcription factors ; Tumor necrosis factor ; tumor necrosis factor-alpha ; Tumor Necrosis Factor-alpha - blood ; Tumor Necrosis Factor-alpha - genetics ; Tumor necrosis factor-TNF
É parte de: Balkan medical journal, 2018-01, Vol.35 (1), p.30-35
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The humoral system is activated and various cytokines are released due to infections in tissues and traumatic damage. Nuclear factor-kappa B dimers are encoded by nuclear factor-kappa B genes and regulate transcription of several crucial proteins of inflammation such as tumour necrosis factor-alpha. To investigate the possible effect of polymorphisms on tumour necrosis factor-alpha serum levels with clinical and prognostic parameters of sepsis by determining the nuclear factor-kappa B-1-94 ins/del ATTG and tumour necrosis factor-alpha (-308 G/A) gene polymorphisms and tumour necrosis factor-alpha serum levels. Case-control study. Seventy-two patients with sepsis and 104 healthy controls were included in the study. In order to determine the polymorphisms of nuclear factor-kappa B-1-94 ins/del ATTG and tumour necrosis factor-alpha (-308 G/A), polymerase chain reaction-restriction fragment length polymorphism analysis was performed and serum tumour necrosis factor-alpha levels were determined using an enzyme-linked immunosorbent assay. We observed no significant differences in tumour necrosis factor-alpha serum levels between the study groups. In the patient group, an increase in the tumour necrosis factor-alpha serum levels in patients carrying the tumour necrosis factor-alpha (-308 G/A) A allele compared to those without the A allele was found to be statistically significant. Additionally, an increase in the tumour necrosis factor-alpha serum levels in patients carrying tumour necrosis factor-alpha (-308 G/A) AA genotype compared with patients carrying the AG or GG genotypes was statistically significant. No significant differences were found in these 2 polymorphisms between the patient and control groups (p>0.05). Our results showed the AA genotype and the A allele of the tumour necrosis factor-alpha (-308 G/A) polymorphism may be used as a predictor of elevated tumour necrosis factor-alpha levels in patients with sepsis.
Editor: Turkey: Galenos Yayinevi Tic. Ltd
Idioma: Inglês;Turco

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Tumour Necrosis Factor-alpha and Nuclear Factor-kappa B Gene Variants in Sepsis

Acar, Leyla ; Atalan, Nazan ; Karagedik, E Hande ; Ergen, Arzu Koçak,Zafer

Turkey: Galenos Yayinevi Tic. Ltd

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