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Early Variations of Circulating Interleukin-6 and Interleukin-10 Levels During Thoracic Radiotherapy Are Predictive for Radiation Pneumonitis

ARPIN, Dominique ; PEROL, David ; ETIENNE-MASTROIANNI, Bénédicte ; COTTIN, Vincent ; PEROL, Maurice ; GUERIN, Jean-Claude ; CORDIER, Jean-Francois ; CARRIE, Christian ; BLAY, Jean-Yves ; FALCHERO, Lionel ; CLAUDE, Line ; VUILLERMOZ-BLAS, Sylvie ; MARTEL-LAFAY, Isabelle ; GINESTET, Chantal ; ALBERTI, Laurent ; NOSOV, Dimitri

Journal of clinical oncology, 2005-12, Vol.23 (34), p.8748-8756 [Periódico revisado por pares]

Baltimore, MD: American Society of Clinical Oncology

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Título:
Early Variations of Circulating Interleukin-6 and Interleukin-10 Levels During Thoracic Radiotherapy Are Predictive for Radiation Pneumonitis
Autor: ARPIN, Dominique ; PEROL, David ; ETIENNE-MASTROIANNI, Bénédicte ; COTTIN, Vincent ; PEROL, Maurice ; GUERIN, Jean-Claude ; CORDIER, Jean-Francois ; CARRIE, Christian ; BLAY, Jean-Yves ; FALCHERO, Lionel ; CLAUDE, Line ; VUILLERMOZ-BLAS, Sylvie ; MARTEL-LAFAY, Isabelle ; GINESTET, Chantal ; ALBERTI, Laurent ; NOSOV, Dimitri
Assuntos: Adult ; Aged ; Biomarkers - blood ; Carcinoma, Non-Small-Cell Lung - blood ; Carcinoma, Non-Small-Cell Lung - radiotherapy ; Female ; Follow-Up Studies ; Humans ; Interleukin-10 - blood ; Interleukin-6 - blood ; Life Sciences ; Lung Neoplasms - blood ; Lung Neoplasms - radiotherapy ; Male ; Middle Aged ; Multivariate Analysis ; Predictive Value of Tests ; Prospective Studies ; Radiation Pneumonitis - blood ; Radiation Pneumonitis - diagnosis ; Radiation Pneumonitis - etiology ; Radiotherapy, Conformal - adverse effects ; Radiotherapy, Conformal - methods ; Time Factors ; Treatment Outcome ; Tumor Necrosis Factor-alpha - metabolism
É parte de: Journal of clinical oncology, 2005-12, Vol.23 (34), p.8748-8756
Descrição: To investigate variations of circulating serum levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha), and interleukin-10 (IL-10) during three-dimensional conformal radiation therapy (3D-CRT) in patients with non-small-cell lung cancer and correlate these variations with the occurrence of radiation pneumonitis. Ninety-six patients receiving 3D-CRT for stage I to III disease were evaluated prospectively. Circulating cytokine levels were determined before, every 2 weeks during, and at the end of treatment. Radiation pneumonitis was evaluated prospectively between 6 and 8 weeks after 3D-CRT. The predictive value of clinical, dosimetric, and biologic (cytokine levels) factors was evaluated both in univariate and multivariate analyses. Forty patients (44%) experienced score 1 or more radiation pneumonitis. No association was found between baseline cytokine levels and the risk of radiation pneumonitis. In the whole population, mean levels of TNFalpha, IL-6, and IL-10 remained stable during radiotherapy. IL-6 levels were significantly higher (P = .047) during 3D-CRT in patients with radiation pneumonitis. In the multivariate analysis, covariations of IL-6 and IL-10 levels during the first 2 weeks of 3D-CRT were evidenced as independently predictive of radiation pneumonitis in this series (P = .011). Early variations of circulating IL-6 and IL-10 levels during 3D-CRT are significantly associated with the risk of radiation pneumonitis. Variations of circulating IL-6 and IL-10 levels during 3D-CRT may serve as independent predictive factors for this complication.
Editor: Baltimore, MD: American Society of Clinical Oncology
Idioma: Inglês;Russo

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Early Variations of Circulating Interleukin-6 and Interleukin-10 Levels During Thoracic Radiotherapy Are Predictive for Radiation Pneumonitis

Baltimore, MD: American Society of Clinical Oncology

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