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Hepatitis C Virus-Associated Cancers

Yi, Zhigang ; Yuan, Zhenghong

Advances in experimental medicine and biology, 2017, Vol.1018, p.129-146 [Periódico revisado por pares]

Singapore: Springer

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Título:
Hepatitis C Virus-Associated Cancers
Autor: Yi, Zhigang ; Yuan, Zhenghong
Assuntos: Antiviral Agents - therapeutic use ; Carcinoma, Hepatocellular - drug therapy ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - virology ; Cell Transformation, Neoplastic - drug effects ; Chronic infection ; Direct-acting antivirals ; Fibrogenesis ; Hepacivirus - drug effects ; Hepacivirus - pathogenicity ; Hepatic stellate cells ; Hepatic Stellate Cells - pathology ; Hepatic Stellate Cells - virology ; Hepatitis C virus ; Hepatitis C, Chronic - drug therapy ; Hepatitis C, Chronic - virology ; Hepatocellular carcinoma ; Humans ; Immunity, Innate - drug effects ; Inflammation ; Inflammation - drug therapy ; Inflammation - genetics ; Inflammation - virology ; Liver - pathology ; Liver - virology ; Liver Neoplasms - drug therapy ; Liver Neoplasms - genetics ; Liver Neoplasms - virology ; Medical microbiology & virology ; Medical parasitology ; Oncology ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Steatosis ; Transforming growth factor
É parte de: Advances in experimental medicine and biology, 2017, Vol.1018, p.129-146
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Most hepatitis C virus (HCV) infection results in persistent infection. Significant portion of chronic HCV-infected patients develop hepatocellular carcinoma (HCC). Chronic hepatitis C is also associated with extrahepatic manifestations, including cryoglobulinemia, lymphoma, insulin resistance, type 2 diabetes, and neurological disorders. The molecular mechanisms of how HCV infection causes liver cancer are largely unknown. HCV replication or viral proteins may perturb cellular hemostasis and induce the generation of reactive oxygen species (ROS); viral components or viral replication products act as agonist to trigger innate immune response and cause chronic inflammation. Within the liver, non-hepatocytes such as hepatic stellate cell (HSC) are activated upon HCV infection to provide the major source of extracellular proteins and play important roles in fibrogenesis. With the great achievements of HCV treatment, especially the direct-acting antivirals (DAAs) against HCV, HCV eradication is possible. However, until now there are only very limited data on the effect of DAA-based anti-HCV treatment on HCC patients.
Títulos relacionados: Advances in Experimental Medicine and Biology
Editor: Singapore: Springer
Idioma: Inglês

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Hepatitis C Virus-Associated Cancers

Yi, Zhigang ; Yuan, Zhenghong

Singapore: Springer

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