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Effects of Cardiotoxins from Naja oxiana Cobra Venom on Rat Heart Muscle and Aorta: A Comparative Study of Toxin-Induced Contraction Mechanisms

Averin, Alexey S ; Nenov, Miroslav N ; Starkov, Vladislav G ; Tsetlin, Victor I ; Utkin, Yuri N

Toxins, 2022-01, Vol.14 (2), p.88 [Periódico revisado por pares]

Switzerland: MDPI AG

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Effects of Cardiotoxins from Naja oxiana Cobra Venom on Rat Heart Muscle and Aorta: A Comparative Study of Toxin-Induced Contraction Mechanisms
Autor: Averin, Alexey S ; Nenov, Miroslav N ; Starkov, Vladislav G ; Tsetlin, Victor I ; Utkin, Yuri N
Assuntos: Amino acids ; Animals ; Aorta ; Aorta - drug effects ; Aorta - physiology ; Blood vessels ; Calcium channels (L-type) ; Calcium influx ; Calcium ions ; Cardiac muscle ; Cardiomyocytes ; cardiotoxin ; Cardiotoxins ; Cardiotoxins - pharmacology ; Cardiovascular system ; Comparative analysis ; Comparative studies ; contraction ; contracture ; Coronary vessels ; Elapid Venoms ; Experiments ; Heart ; Male ; Muscle contraction ; Muscle Contraction - drug effects ; Muscles ; Naja naja ; Naja oxiana ; Nifedipine ; papillary muscle ; Papillary Muscles - drug effects ; Papillary Muscles - physiology ; Rats ; Rats, Wistar ; Smooth muscle ; Toxins ; Vasoconstriction - drug effects ; Venom
É parte de: Toxins, 2022-01, Vol.14 (2), p.88
Descrição: Cardiotoxins (CaTxs) are a group of snake toxins that affect the cardiovascular system (CVS). Two types (S and P) of CaTxs are known, but the exact differences in the effects of these types on CVS have not been thoroughly studied. We investigated cellular mechanisms of action on CVS for cobra CaTxs CTX-1 (S-type) and CTX-2 (P-type) focusing on the papillary muscle (PM) contractility and contraction of aortic rings (AR) supplemented by pharmacological analysis. It was found that CTX-1 and CTX-2 exerted dose-dependent effects manifested in PM contracture and AR contraction. CTX-2 impaired functions of PM and AR more strongly than CTX-1. Effects of CaTxs on PM were significantly reduced by nifedipine, an L-type Ca channel blocker, and by KB-R7943, an inhibitor of reverse-mode Na /Ca exchange. Furthermore, 2-aminoethoxydiphenyl borate, an inhibitor of store-operated calcium entry, partially restored PM contractility damaged by CaTxs. The CaTx influence on AR contracture was significantly reduced by nifedipine and KB-R7943. The involvement of reverse-mode Na /Ca exchange in the effect of CaTxs on the rat aorta was shown for the first time. The results obtained indicate that CaTx effects on CVS are mainly associated with disturbance of transporting systems responsible for the Ca influx.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Effects of Cardiotoxins from Naja oxiana Cobra Venom on Rat Heart Muscle and Aorta: A Comparative Study of Toxin-Induced Contraction Mechanisms

Averin, Alexey S ; Nenov, Miroslav N ; Starkov, Vladislav G ; Tsetlin, Victor I ; Utkin, Yuri N

Switzerland: MDPI AG

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