Idioma:

Comparison of outcomes after unrelated cord blood and unmanipulated haploidentical stem cell transplantation in adults with acute leukemia

Ruggeri, A ; Labopin, M ; Sanz, G ; Piemontese, S ; Arcese, W ; Bacigalupo, A ; Blaise, D ; Bosi, A ; Huang, H ; Karakasis, D ; Koc, Y ; Michallet, M ; Picardi, A ; Sanz, J ; Santarone, S ; Sengelov, H ; Sierra, J ; Vincent, L ; Volt, F ; Nagler, A ; Gluckman, E ; Ciceri, F ; Rocha, V ; Mohty, M

Leukemia, 2015-09, Vol.29 (9), p.1891-1900 [Periódico revisado por pares]

England: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Comparison of outcomes after unrelated cord blood and unmanipulated haploidentical stem cell transplantation in adults with acute leukemia
Autor: Ruggeri, A ; Labopin, M ; Sanz, G ; Piemontese, S ; Arcese, W ; Bacigalupo, A ; Blaise, D ; Bosi, A ; Huang, H ; Karakasis, D ; Koc, Y ; Michallet, M ; Picardi, A ; Sanz, J ; Santarone, S ; Sengelov, H ; Sierra, J ; Vincent, L ; Volt, F ; Nagler, A ; Gluckman, E ; Ciceri, F ; Rocha, V ; Mohty, M
Assuntos: Acute lymphoblastic leukemia ; Acute lymphocytic leukemia ; Acute myeloid leukemia ; Adolescent ; Adult ; Adults ; Aged ; Antigens ; Blood ; Cancer ; Comparative analysis ; Cord blood ; Cord Blood Stem Cell Transplantation ; Failure analysis ; Female ; Fetal blood ; Follow-Up Studies ; Graft rejection ; Graft Survival ; Graft vs Host Disease - etiology ; Graft vs Host Disease - prevention & control ; Graft-versus-host reaction ; Grafts ; Hematology ; Hematopoietic Stem Cell Transplantation ; Histocompatibility antigen HLA ; Histocompatibility Testing ; HLA Antigens - immunology ; Human health and pathology ; Humans ; Incidence ; Leukemia ; Leukemia, Myeloid, Acute - immunology ; Leukemia, Myeloid, Acute - mortality ; Leukemia, Myeloid, Acute - therapy ; Leukocytes ; Life Sciences ; Lymphatic leukemia ; Male ; Methods ; Middle Aged ; Multivariate analysis ; Myeloid leukemia ; Oncology, Experimental ; Patient outcomes ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy ; Recurrence ; Risk Factors ; Statistical analysis ; Stem cell transplantation ; Stem cells ; Transplantation ; Transplantation Conditioning ; Transplantation, Homologous ; Treatment Outcome ; Young Adult
É parte de: Leukemia, 2015-09, Vol.29 (9), p.1891-1900
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Outcomes after unmanipulated haploidentical stem cell transplantation (Haplo) and after unrelated cord blood transplantation (UCBT) are encouraging and have become alternative options to treat patients with high-risk acute leukemia without human leukocyte antigen (HLA) matched donor. We compared outcomes after UCBT and Haplo in adults with de novo acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Median follow-up was 24 months. Analysis was performed separately for patients with AML, n=918 (Haplo=360, UCBT=558) and ALL, n=528 (Haplo=158 and UCBT=370). UCBT was associated with delayed engraftment and higher graft failure in both AML and ALL recipients. In multivariate analysis, UCBT was associated with lower incidence of chronic graft-vs-host disease both in the AML group (hazard ratio (HR)=0.63, P=0.008) and in the ALL group (HR=0.58, P=0.01). Not statistically significant differences were observed between Haplo and UCBT for relapse incidence (HR=0.95, P=0.76 for AML and HR=0.82, P=0.31 for ALL), non-relapse mortality (HR=1.16, P=0.47 for AML and HR=1.23, P=0.23 for ALL) and leukemia-free survival (HR 0.78, P=0.78 for AML and HR=1.00, P=0.84 for ALL). There were no statistically differences on main outcomes after unmanipulated Haplo and UCBT, and both approaches are valid for acute leukemia patients lacking a HLA matched donor. Both strategies expand the donor pool for patients in need.
Editor: England: Nature Publishing Group
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 4 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Comparison of outcomes after unrelated cord blood and unmanipulated haploidentical stem cell transplantation in adults with acute leukemia

Ruggeri, A ; Labopin, M ; Sanz, G ; Piemontese, S ; Arcese, W ; Bacigalupo, A ; Blaise, D ; Bosi, A ; Huang, H ; Karakasis, D ; Koc, Y ; Michallet, M ; Picardi, A ; Sanz, J ; Santarone, S ; Sengelov, H ; Sierra, J ; Vincent, L ; Volt, F ; Nagler, A ; Gluckman, E ; Ciceri, F ; Rocha, V ; Mohty, M

England: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.