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Evolution of Imprinting: Imprinted Gene Function in Human Disease

Dickins, Benjamin JA ; Kelsey, Gavin

eLS, 2008

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Título:
Evolution of Imprinting: Imprinted Gene Function in Human Disease
Autor: Dickins, Benjamin JA ; Kelsey, Gavin
Assuntos: Chromosomes and Chromatin Modifications ; Epigenetics and Disease ; Evolution & Diversity of Life ; Evolution of Coding and Functional Modules ; Evolutionary Genomics ; Genetics & Disease ; Human Evolution ; Molecular Biology ; Molecular Evolution
É parte de: eLS, 2008
Descrição: A subset of genes in mammals, known as imprinted genes, show a conditional expression strategy in which transcription depends on an allele's parental origin. Several explanations have been advanced to explain this phenomenon and these, with varying levels of success, predict the functions of imprinted genes. After outlining these explanations, we summarize what is known about human genetic disorders involving abnormal expression of imprinted genes and ask what this can tell us about the evolution of imprinting.
Editor: Chichester, UK: John Wiley & Sons, Ltd
Formato: 11
Idioma: Inglês

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