skip to main content
Idioma:

Variability and predictors of urinary concentrations of organophosphate flame retardant metabolites among pregnant women in Rhode Island

Romano, Megan E ; Hawley, Nicola L ; Eliot, Melissa ; Calafat, Antonia M ; Jayatilaka, Nayana K ; Kelsey, Karl ; McGarvey, Stephen ; Phipps, Maureen G ; Savitz, David A ; Werner, Erika F ; Braun, Joseph M

Environmental health, 2017-04, Vol.16 (1), p.40-40, Article 40 [Periódico revisado por pares]

England: BioMed Central

Texto completo disponível

Citações Citado por
  • Título:
    Variability and predictors of urinary concentrations of organophosphate flame retardant metabolites among pregnant women in Rhode Island
  • Autor: Romano, Megan E ; Hawley, Nicola L ; Eliot, Melissa ; Calafat, Antonia M ; Jayatilaka, Nayana K ; Kelsey, Karl ; McGarvey, Stephen ; Phipps, Maureen G ; Savitz, David A ; Werner, Erika F ; Braun, Joseph M
  • Assuntos: Adult ; Body Mass Index ; Body Weight ; Continental Population Groups ; Diet ; Educational Status ; Environmental Monitoring - methods ; Environmental Pollutants - urine ; Female ; Flame retardants ; Flame Retardants - analysis ; Humans ; Income ; Organophosphates - urine ; Parity ; Pilot Projects ; Pregnancy ; Pregnancy - urine ; Reproducibility of Results ; Rhode Island ; Urine metabolites
  • É parte de: Environmental health, 2017-04, Vol.16 (1), p.40-40, Article 40
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Organophospate flame retardants (PFRs) are chemicals of emerging concern due to restrictions on polybrominated diphenyl ether flame retardant formulations. We describe the occurrence, variability, and predictors of urinary metabolites of PFRs among pregnant women. In 2014-2015, 59 women from Providence, RI provided up to 3 spot urine samples during pregnancy (~12, 28, and 35 weeks' gestation). We created a pooled urine sample per woman and measured nine relevant metabolites in individual and pooled samples. We used linear mixed models to calculate intraclass correlation coefficients (ICCs) across the 3 measurements and to assess sociodemographic and dietary predictors of PFRs. The median (IQR) of bis-2-chloroethyl phosphate (BCEP), bis(1,3-dichloro-2-propyl) phosphate (BDCPP), and diphenyl phosphate (DPhP), the metabolites most frequently detected, from pooled samples were: 0.31 μg/L (0.17-0.54), 1.18 μg/L (0.64-2.19), 0.93 μg/L (0.72-1.97), respectively. We observed fair to good reproducibility for BCEP (ICC = 0.50), BDCPP (ICC = 0.60), and DPhP (ICC = 0.43), and excellent agreement between the urinary flame retardant metabolite concentrations averaged across pregnancy versus pooled urine sample concentrations for BCEP (ICC = 0.95), BDCPP (ICC = 0.89), and DPhP (ICC = 0.93). Adjusting for pertinent sociodemographic factors and gestational week of urine collection, each 1 kg increase in pre-pregnancy weight was associated with greater BCEP (1.1%; 95% CI: 0.1, 2.1), BDCPP (1.5%; 95% CI: 0.3, 2.7), and DPhP (0.5%; 95% CI: 0.0, 1.1). Dietary factors were generally not associated with urinary flame retardant metabolites. Urinary concentrations of BCEP, BDCPP, and DPhP were frequently detected among women in this pilot study and had fair reproducibility across pregnancy. Body size may be an important predictor of urinary flame retardant metabolite concentrations.
  • Editor: England: BioMed Central
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.