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Current Developments in the Immunology of Psoriasis

Grän, Franziska ; Kerstan, Andreas ; Serfling, Edgar ; Goebeler, Matthias ; Muhammad, Khalid

The Yale journal of biology & medicine, 2020-03, Vol.93 (1), p.97-110 [Periódico revisado por pares]

United States: Yale Journal of Biology and Medicine

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Título:
Current Developments in the Immunology of Psoriasis
Autor: Grän, Franziska ; Kerstan, Andreas ; Serfling, Edgar ; Goebeler, Matthias ; Muhammad, Khalid
Assuntos: Antigens ; Biological Products - pharmacology ; Cell activation ; Cytokines ; Dendritic cells ; Gene expression ; Genomes ; Humans ; Immune system ; Immunity, Innate - drug effects ; Immunity, Innate - physiology ; Immunology ; Immunosuppressive Agents - pharmacology ; Inflammation ; Inflammatory diseases ; Keratinocytes ; Lymphocytes ; Lymphocytes B ; Lymphocytes T ; Neutrophils ; Pathogenesis ; Pathogenicity ; Peptides ; Psoriasis ; Psoriasis - immunology ; Psoriasis - pathology ; Psoriasis - therapy ; Review ; Signal transduction ; Skin ; Skin - immunology ; Skin - pathology ; Skin diseases
É parte de: The Yale journal of biology & medicine, 2020-03, Vol.93 (1), p.97-110
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Psoriasis is a frequent inflammatory skin disease. Fundamental research on the pathogenesis of psoriasis has substantially increased our understanding of skin immunology, which has helped to introduce innovative and highly effective therapies. Psoriasis is a largely T lymphocyte-mediated disease in which activation of innate immune cells and pathogenic T cells result in skin inflammation and hyperproliferation of keratinocytes. B cells have thus far largely been neglected regarding their role for the pathogenesis of psoriasis. However, recent data shed light on their role in inflammatory skin diseases. Interestingly, interleukin (IL)-10-producing regulatory B cells have been assumed to ameliorate psoriasis. In this review, we will discuss the development of disease, pathogenicity, and current developments in therapeutic options. We describe different roles of T cells, B cells, and cytokines for the immunopathology and disease course of psoriasis.
Editor: United States: Yale Journal of Biology and Medicine
Idioma: Inglês

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Current Developments in the Immunology of Psoriasis

Grän, Franziska ; Kerstan, Andreas ; Serfling, Edgar ; Goebeler, Matthias ; Muhammad, Khalid

United States: Yale Journal of Biology and Medicine

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