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Learning Induces Long-Term Potentiation in the Hippocampus

Whitlock, Jonathan R ; Heynen, Arnold J ; Shuler, Marshall G ; Bear, Mark F

Science (American Association for the Advancement of Science), 2006-08, Vol.313 (5790), p.1093-1097 [Periódico revisado por pares]

Washington, DC: American Association for the Advancement of Science

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Título:
Learning Induces Long-Term Potentiation in the Hippocampus
Autor: Whitlock, Jonathan R ; Heynen, Arnold J ; Shuler, Marshall G ; Bear, Mark F
Assuntos: Animal training ; Animals ; Avoidance Learning - physiology ; Behavioral neuroscience ; Biological and medical sciences ; Brain research ; Central nervous system ; Conditioning (Psychology) ; Electric Stimulation ; Electrodes ; Electrodes, Implanted ; Electrophysiology ; Excitatory Postsynaptic Potentials ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Hippocampus - physiology ; Learning ; Long term depression ; Long term potentiation ; Long-Term Potentiation - physiology ; Male ; Memory ; Memory - physiology ; Neurosciences ; Phosphorylation ; Phosphoserine - metabolism ; Rats ; Rats, Long-Evans ; Receptors, AMPA - metabolism ; Research Article ; Synapses ; Synapses - metabolism ; Synapses - physiology ; Synaptic Transmission ; Vertebrates: nervous system and sense organs
É parte de: Science (American Association for the Advancement of Science), 2006-08, Vol.313 (5790), p.1093-1097
Notas: http://www.scienceonline.org/
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Descrição: Years of intensive investigation have yielded a sophisticated understanding of long-term potentiation (LTP) induced in hippocampal area CA1 by high-frequency stimulation (HFS). These efforts have been motivated by the belief that similar synaptic modifications occur during memory formation, but it has never been shown that learning actually induces LTP in CA1. We found that one-trial inhibitory avoidance learning in rats produced the same changes in hippocampal glutamate receptors as induction of LTP with HFS and caused a spatially restricted increase in the amplitude of evoked synaptic transmission in CA1 in vivo. Because the learning-induced synaptic potentiation occluded HFS-induced LTP, we conclude that inhibitory avoidance training induces LTP in CA1.
Editor: Washington, DC: American Association for the Advancement of Science
Idioma: Inglês

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Learning Induces Long-Term Potentiation in the Hippocampus

Whitlock, Jonathan R ; Heynen, Arnold J ; Shuler, Marshall G ; Bear, Mark F

Washington, DC: American Association for the Advancement of Science

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