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Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Bastard, Paul ; Rosen, Lindsey B ; Zhang, Qian ; Michailidis, Eleftherios ; Hoffmann, Hans-Heinrich ; Zhang, Yu ; Dorgham, Karim ; Philippot, Quentin ; Rosain, Jérémie ; Béziat, Vivien ; Manry, Jérémy ; Shaw, Elana ; Haljasmägi, Liis ; Peterson, Pärt ; Lorenzo, Lazaro ; Bizien, Lucy ; Trouillet-Assant, Sophie ; Dobbs, Kerry ; de Jesus, Adriana Almeida ; Belot, Alexandre ; Kallaste, Anne ; Catherinot, Emilie ; Tandjaoui-Lambiotte, Yacine ; Le Pen, Jeremie ; Kerner, Gaspard ; Bigio, Benedetta ; Seeleuthner, Yoann ; Yang, Rui ; Bolze, Alexandre ; Spaan, András N ; Delmonte, Ottavia M ; Abers, Michael S ; Aiuti, Alessandro ; Casari, Giorgio ; Lampasona, Vito ; Piemonti, Lorenzo ; Ciceri, Fabio ; Bilguvar, Kaya ; Lifton, Richard P ; Vasse, Marc ; Smadja, David M ; Migaud, Mélanie ; Hadjadj, Jérome ; Terrier, Benjamin ; Duffy, Darragh ; Quintana-Murci, Lluis ; van de Beek, Diederik ; Roussel, Lucie ; Vinh, Donald C ; Tangye, Stuart G ; Haerynck, Filomeen ; Dalmau, David ; Martinez-Picado, Javier ; Brodin, Petter ; Nussenzweig, Michel C ; Boisson-Dupuis, Stéphanie ; Rodríguez-Gallego, Carlos ; Vogt, Guillaume ; Mogensen, Trine H ; Oler, Andrew J ; Gu, Jingwen ; Burbelo, Peter D ; Cohen, Jeffrey I ; Biondi, Andrea ; Bettini, Laura Rachele ; D'Angio, Mariella ; Bonfanti, Paolo ; Rossignol, Patrick ; Mayaux, Julien ; Rieux-Laucat, Frédéric ; Husebye, Eystein S ; Fusco, Francesca ; Ursini, Matilde Valeria ; Imberti, Luisa ; Sottini, Alessandra ; Paghera, Simone ; Quiros-Roldan, Eugenia ; Rossi, Camillo ; Castagnoli, Riccardo ; Montagna, Daniela ; Licari, Amelia ; Marseglia, Gian Luigi ; Duval, Xavier ; Ghosn, Jade ; Tsang, John S ; Goldbach-Mansky, Raphaela ; Kisand, Kai ; Lionakis, Michail S ; Puel, Anne ; Zhang, Shen-Ying ; Holland, Steven M ; Gorochov, Guy ; Jouanguy, Emmanuelle ; Rice, Charles M ; Cobat, Aurélie ; Notarangelo, Luigi D ; Abel, Laurent ; Su, Helen C ; Casanova, Jean-Laurent

Science (American Association for the Advancement of Science), 2020-10, Vol.370 (6515), p.423 [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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Título:
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Autor: Bastard, Paul ; Rosen, Lindsey B ; Zhang, Qian ; Michailidis, Eleftherios ; Hoffmann, Hans-Heinrich ; Zhang, Yu ; Dorgham, Karim ; Philippot, Quentin ; Rosain, Jérémie ; Béziat, Vivien ; Manry, Jérémy ; Shaw, Elana ; Haljasmägi, Liis ; Peterson, Pärt ; Lorenzo, Lazaro ; Bizien, Lucy ; Trouillet-Assant, Sophie ; Dobbs, Kerry ; de Jesus, Adriana Almeida ; Belot, Alexandre ; Kallaste, Anne ; Catherinot, Emilie ; Tandjaoui-Lambiotte, Yacine ; Le Pen, Jeremie ; Kerner, Gaspard ; Bigio, Benedetta ; Seeleuthner, Yoann ; Yang, Rui ; Bolze, Alexandre ; Spaan, András N ; Delmonte, Ottavia M ; Abers, Michael S ; Aiuti, Alessandro ; Casari, Giorgio ; Lampasona, Vito ; Piemonti, Lorenzo ; Ciceri, Fabio ; Bilguvar, Kaya ; Lifton, Richard P ; Vasse, Marc ; Smadja, David M ; Migaud, Mélanie ; Hadjadj, Jérome ; Terrier, Benjamin ; Duffy, Darragh ; Quintana-Murci, Lluis ; van de Beek, Diederik ; Roussel, Lucie ; Vinh, Donald C ; Tangye, Stuart G ; Haerynck, Filomeen ; Dalmau, David ; Martinez-Picado, Javier ; Brodin, Petter ; Nussenzweig, Michel C ; Boisson-Dupuis, Stéphanie ; Rodríguez-Gallego, Carlos ; Vogt, Guillaume ; Mogensen, Trine H ; Oler, Andrew J ; Gu, Jingwen ; Burbelo, Peter D ; Cohen, Jeffrey I ; Biondi, Andrea ; Bettini, Laura Rachele ; D'Angio, Mariella ; Bonfanti, Paolo ; Rossignol, Patrick ; Mayaux, Julien ; Rieux-Laucat, Frédéric ; Husebye, Eystein S ; Fusco, Francesca ; Ursini, Matilde Valeria ; Imberti, Luisa ; Sottini, Alessandra ; Paghera, Simone ; Quiros-Roldan, Eugenia ; Rossi, Camillo ; Castagnoli, Riccardo ; Montagna, Daniela ; Licari, Amelia ; Marseglia, Gian Luigi ; Duval, Xavier ; Ghosn, Jade ; Tsang, John S ; Goldbach-Mansky, Raphaela ; Kisand, Kai ; Lionakis, Michail S ; Puel, Anne ; Zhang, Shen-Ying ; Holland, Steven M ; Gorochov, Guy ; Jouanguy, Emmanuelle ; Rice, Charles M ; Cobat, Aurélie ; Notarangelo, Luigi D ; Abel, Laurent ; Su, Helen C ; Casanova, Jean-Laurent
Assuntos: Adult ; Aged ; Aged, 80 and over ; Antibodies ; Antibodies, Neutralizing - blood ; Asymptomatic ; Asymptomatic Infections ; Autoantibodies ; Autoantibodies - blood ; Autoimmunity ; Betacoronavirus ; Case-Control Studies ; Control Groups ; Coronaviridae ; Coronavirus Infections - immunology ; Coronaviruses ; COVID-19 ; Critical Illness ; Cytokines ; Disease ; Female ; Genetics ; Health risks ; Hematology ; Human health and pathology ; Humans ; Immune system ; Immunoglobulin G - blood ; Immunoglobulins ; Immunology ; Infections ; Infectious diseases ; Interferon alpha-2 - immunology ; Interferon Type I - immunology ; Life Sciences ; Male ; Males ; Medicin och hälsovetenskap ; Middle Aged ; Mutation ; Online ; Pandemics ; Patients ; Pneumonia ; Pneumonia, Viral - immunology ; Public health ; Respiratory diseases ; Risk factors ; SARS-CoV-2 ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Vaccines ; Viral infections
É parte de: Science (American Association for the Advancement of Science), 2020-10, Vol.370 (6515), p.423
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
These authors contributed equally to this work.
All collaborators and their affiliations appear at the end of this paper.
Descrição: Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
Editor: United States: The American Association for the Advancement of Science
Idioma: Inglês

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Autoantibodies against type I IFNs in patients with life-threatening COVID-19

United States: The American Association for the Advancement of Science

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