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Landscape of Somatic Retrotransposition in Human Cancers

Lee, Eunjung ; Iskow, Rebecca ; Yang, Lixing ; Gokcumen, Omer ; Haseley, Psalm ; Luquette, Lovelace J. ; Lohr, Jens G. ; Harris, Christopher C. ; Ding, Li ; Wilson, Richard K. ; Wheeler, David A. ; Gibbs, Richard A. ; Kucherlapati, Raju ; Lee, Charles ; Kharchenko, Peter V. ; Park, Peter J.

Science (American Association for the Advancement of Science), 2012-08, Vol.337 (6097), p.967-971 [Periódico revisado por pares]

Washington, DC: American Association for the Advancement of Science

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Título:
Landscape of Somatic Retrotransposition in Human Cancers
Autor: Lee, Eunjung ; Iskow, Rebecca ; Yang, Lixing ; Gokcumen, Omer ; Haseley, Psalm ; Luquette, Lovelace J. ; Lohr, Jens G. ; Harris, Christopher C. ; Ding, Li ; Wilson, Richard K. ; Wheeler, David A. ; Gibbs, Richard A. ; Kucherlapati, Raju ; Lee, Charles ; Kharchenko, Peter V. ; Park, Peter J.
Assuntos: Base Sequence ; Biological and medical sciences ; Blood ; Brain ; Cancer ; Cell Transformation, Neoplastic ; Cellular biology ; Colorectal neoplasms ; Colorectal Neoplasms - genetics ; DNA Methylation ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic ; Genes ; Genes, Neoplasm ; Genetic mutation ; Genetics ; Genome, Human ; Genomes ; Genomics ; Germ cells ; Glioblastoma - genetics ; Humans ; Landscapes ; Long Interspersed Nucleotide Elements ; Male ; Mammals ; Medical sciences ; Microsatellite Instability ; Molecular Sequence Annotation ; Molecular Sequence Data ; Multiple Myeloma - genetics ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Mutagenesis ; Mutagenesis, Insertional ; Mutation ; Ovarian Neoplasms - genetics ; Progressions ; Prostatic Neoplasms - genetics ; Retroelements ; Sequence Analysis, DNA ; Sequencing ; Tracheoesophageal fistula ; Tumors ; Untranslated regions
É parte de: Science (American Association for the Advancement of Science), 2012-08, Vol.337 (6097), p.967-971
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Transposable elements (TEs) are abundant in the human genome, and some are capable of generating new insertions through RNA intermediates. In cancer, the disruption of cellular mechanisms that normally suppress TE activity may facilitate mutagenic retrotranspositions. We performed single-nucleotide resolution analysis of TE insertions in 43 high-coverage whole-genome sequencing data sets from five cancer types. We identified 194 high-confidence somatic TE insertions, as well as thousands of polymorphic TE insertions in matched normal genomes. Somatic insertions were present in epithelial tumors but not in blood or brain cancers. Somatic L1 insertions tend to occur in genes that are commonly mutated in cancer, disrupt the expression of the target genes, and are biased toward regions of cancer-specific DNA hypomethylation, highlighting their potential impact in tumorigenesis.
Editor: Washington, DC: American Association for the Advancement of Science
Idioma: Inglês

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Landscape of Somatic Retrotransposition in Human Cancers

Lee, Eunjung ; Iskow, Rebecca ; Yang, Lixing ; Gokcumen, Omer ; Haseley, Psalm ; Luquette, Lovelace J. ; Lohr, Jens G. ; Harris, Christopher C. ; Ding, Li ; Wilson, Richard K. ; Wheeler, David A. ; Gibbs, Richard A. ; Kucherlapati, Raju ; Lee, Charles ; Kharchenko, Peter V. ; Park, Peter J.

Washington, DC: American Association for the Advancement of Science

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