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Perchlorate Reduction by Yeast for Mars Exploration

Sharma, Alaisha

Ames Research Center 2015

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  • Título:
    Perchlorate Reduction by Yeast for Mars Exploration
  • Autor: Sharma, Alaisha
  • Assuntos: Exobiology ; Inorganic, Organic And Physical Chemistry ; Life Sciences (General)
  • Notas: ARC
    Ames Research Center
    Moffett Field, CA
    ARC-E-DAA-TN24721
  • Descrição: Martian soil contains high levels (0.6 percentage by mass) of calcium perchlorate (Ca(ClO4)2), which readily dissociates into calcium and the perchlorate ion (ClO4−) in water. Even in trace amounts, perchlorates are toxic to humans and have been implicated in thyroid dysfunction. Devising methods to lessen perchlorate contamination is crucial to minimizing the health risks associated with human exploration and colonization of Mars. We designed a perchlorate reduction pathway, which sequentially reduces perchlorate to chloride (Cl−) and oxygen (O2), for implementation in the yeast Saccharomyces cerevisiae. Using genes obtained from perchlorate reducing bacteria Azospira oryzae and Dechloromonas aromatica, we plan to assemble this pathway directly within S. cerevisiae through recombinational cloning. A perchlorate reduction pathway would enable S. cerevisiae to lower perchlorate levels and produce oxygen, which may be harvested or used directly by S. cerevisiae for aerobic growth and compound synthesis. Moreover, using perchlorate as an external electron acceptor could improve the efficiency of redox-imbalanced production pathways in yeast. Although several perchlorate reducing bacteria have been identified and utilized in water treatment systems on Earth, the widespread use of S. cerevisiae as a synthetic biology platform justifies the development of a perchlorate reducing strain for implementation on Mars.
  • Editor: Ames Research Center
  • Data de criação/publicação: 2015
  • Idioma: Inglês
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