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Leptin is not associated independently with hypertension in Japanese-Brazilian women

Almeida-Pititto, B ; Gimeno, S G A ; Freire, R D ; Ribeiro-Filho, F F ; Ferreira, S R G

Brazilian journal of medical and biological research, 2006-01, Vol.39 (1), p.99-105 [Periódico revisado por pares]

Brazil: Associação Brasileira de Divulgação Científica

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Título:
Leptin is not associated independently with hypertension in Japanese-Brazilian women
Autor: Almeida-Pititto, B ; Gimeno, S G A ; Freire, R D ; Ribeiro-Filho, F F ; Ferreira, S R G
Assuntos: Abdominal Fat - physiopathology ; Adult ; BIOLOGY ; Body fat distribution ; Body Mass Index ; Brazil ; C-Reactive Protein - analysis ; Centrally obese ; Cholesterol - blood ; Female ; Humans ; Hypertension ; Hypertension - blood ; Hypertension - ethnology ; Hypertension - physiopathology ; Insulin ; Insulin - blood ; Japan - ethnology ; Leptin ; Leptin - blood ; Logistic Models ; MEDICINE, RESEARCH & EXPERIMENTAL ; Metabolic syndrome ; Middle Aged ; Obesity - blood ; Obesity - ethnology ; Obesity - physiopathology ; Waist-Hip Ratio
É parte de: Brazilian journal of medical and biological research, 2006-01, Vol.39 (1), p.99-105
Descrição: We evaluated the relationship of leptin with hypertension adjusted for body mass index (BMI) and/or waist circumference in a population of Japanese-Brazilian women aged > or = 30 years with centrally distributed adiposity. After excluding diabetic subjects, the study subjects--who participated in a population-based study on the prevalence of metabolic syndrome--showed prevalence rates of obesity (BMI > or = 25 kg/m2) and central adiposity (waist > or = 80 cm) of 32.0 and 37.8%, respectively. The hypertensive group (N = 162) was older, had higher BMI (24.9 +/- 4.2 vs 23.3 +/- 3.4 kg/m2, P < 0.001), waist circumference (81.1 +/- 10.1 vs 76.3 +/- 8.2 cm, P < 0.001) and insulin levels (8.0 +/- 6.2 vs 7.1 +/- 4.9 microU/mL, P < 0.05) than the normotensive group (N = 322) and showed an unfavorable metabolic profile (higher 2-h plasma glucose, C-reactive protein and non-HDL cholesterol levels). Leptin did not differ between groups (8.2 +/- 6.8 vs 7.2 +/- 6.6 ng/mL, P = 0.09, for hypertensive vs normotensive, respectively) and its levels correlated significantly with anthropometric variables but not with blood pressure. Logistic regression analysis indicated that age and waist were independently associated with hypertension but not with homeostasis model assessment of insulin resistance or leptin levels. The lack of an independent association of hypertension with metabolic parameters (2-h glucose, C-reactive protein and non-HDL cholesterol) after adjustment for central adiposity suggested that visceral fat deposition may be the common mediator of the disturbances of the metabolic syndrome. Our data indicate that age and waist are major determinants of hypertension in this population of centrally obese (waist > or = 80 cm) Japanese-Brazilian women, but do not support a role for leptin in the elevation of blood pressure.
Editor: Brazil: Associação Brasileira de Divulgação Científica
Idioma: Inglês;Português

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Leptin is not associated independently with hypertension in Japanese-Brazilian women

Almeida-Pititto, B ; Gimeno, S G A ; Freire, R D ; Ribeiro-Filho, F F ; Ferreira, S R G

Brazil: Associação Brasileira de Divulgação Científica

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