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High-Dose Aspirin Is Required to Influence Plasma Fibrin Network Structure in Patients With Type 1 Diabetes

TEHRANI, Sara ; ANTOVIC, Aleksandra ; MOBARREZ, Fariborz ; MAGEED, Koteiba ; LINS, Per-Eric ; ADAMSON, Ulf ; WALLEN, Hakan N ; JORNESKOG, Gun

Diabetes care, 2012-02, Vol.35 (2), p.404-408 [Periódico revisado por pares]

Alexandria, VA: American Diabetes Association

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Título:
High-Dose Aspirin Is Required to Influence Plasma Fibrin Network Structure in Patients With Type 1 Diabetes
Autor: TEHRANI, Sara ; ANTOVIC, Aleksandra ; MOBARREZ, Fariborz ; MAGEED, Koteiba ; LINS, Per-Eric ; ADAMSON, Ulf ; WALLEN, Hakan N ; JORNESKOG, Gun
Assuntos: Aspirin ; Aspirin - administration & dosage ; Aspirin - therapeutic use ; Biological and medical sciences ; Blood clots ; Care and treatment ; Chromatography, High Pressure Liquid ; Diabetes ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - drug therapy ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes therapy ; Diabetes. Impaired glucose tolerance ; Diabetics ; Dosage and administration ; Drug Administration Schedule ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Fibrin ; Fibrin - metabolism ; Glycated Hemoglobin A - metabolism ; Hospitals ; Humans ; Male ; Medical research ; Medical sciences ; Medicin och hälsovetenskap ; Medicine, Experimental ; Metabolic diseases ; Miscellaneous ; Original Research ; Permeability ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Studies ; Type 1 diabetes
É parte de: Diabetes care, 2012-02, Vol.35 (2), p.404-408
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
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Descrição: Patients with type 1 diabetes form a less permeable fibrin network, which could contribute to their increased risk of cardiovascular disease (CVD). Low-dose aspirin treatment is the standard in the management of CVD; however, the effect seems reduced in patients with diabetes. We investigated the effects of low- and high-dose aspirin treatment on fibrin network formation in patients with type 1 diabetes (primary aim) and the possible interaction between the treatment effects of aspirin on fibrin network permeability and glycemic control in these patients (secondary aim). Forty-eight patients (24 subjects with good [HbA(1c) <7.4%] and 24 subjects with poor [HbA(1c) >8.4%] glycemic control) were randomly assigned to treatment with 75 or 320 mg/day aspirin during 4 weeks in a crossover fashion. A 4-week washout period separated the treatment periods. The plasma fibrin network was assessed by determination of the permeability coefficient (K(s)). Treatment with 75 mg aspirin did not influence fibrin network permeability (K(s)). However, K(s) increased significantly during treatment with 320 mg aspirin (P = 0.004), and a significant treatment effect was seen compared with treatment with 75 mg aspirin (P = 0.009). The increase in K(s) during high-dose aspirin treatment was significant in patients with poor glycemic control (P = 0.02), whereas K(s) only tended to increase in patients with good glycemic control (P = 0.06). A high dose of aspirin is required to influence fibrin network permeability in patients with type 1 diabetes. The observed lack of effect with low-dose aspirin may contribute to aspirin treatment failure in diabetes.
Editor: Alexandria, VA: American Diabetes Association
Idioma: Inglês

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High-Dose Aspirin Is Required to Influence Plasma Fibrin Network Structure in Patients With Type 1 Diabetes

TEHRANI, Sara ; ANTOVIC, Aleksandra ; MOBARREZ, Fariborz ; MAGEED, Koteiba ; LINS, Per-Eric ; ADAMSON, Ulf ; WALLEN, Hakan N ; JORNESKOG, Gun

Alexandria, VA: American Diabetes Association

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