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1,25-Dihydroxyvitamin D3 Alters the Profile of Bone Marrow-Derived Dendritic Cells of NOD Mice

VAN ETTEN, EVELYNE ; DARDENNE, OLIVIER ; GYSEMANS, CONNY ; OVERBERGH, LUT ; MATHIEU, CHANTAL

Annals of the New York Academy of Sciences, 2004-12, Vol.1037 (1), p.186-192 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
1,25-Dihydroxyvitamin D3 Alters the Profile of Bone Marrow-Derived Dendritic Cells of NOD Mice
Autor: VAN ETTEN, EVELYNE ; DARDENNE, OLIVIER ; GYSEMANS, CONNY ; OVERBERGH, LUT ; MATHIEU, CHANTAL
Assuntos: 1,25(OH)2D3 ; 25(OH)2D3 ; Animals ; Antigens, CD - drug effects ; B7-2 Antigen ; Bone Marrow Cells - cytology ; Bone Marrow Cells - drug effects ; Calcitriol - pharmacology ; CD40 Antigens - metabolism ; Cell Separation ; Cells, Cultured ; Culture Media - analysis ; dendritic cells ; Dendritic Cells - cytology ; Dendritic Cells - drug effects ; Enzyme-Linked Immunosorbent Assay ; Female ; Flow Cytometry ; Gene Expression Regulation - drug effects ; Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology ; Intercellular Adhesion Molecule-1 - drug effects ; Interferon-gamma - pharmacology ; Interleukin-10 - biosynthesis ; Interleukin-12 - biosynthesis ; Interleukin-4 - pharmacology ; Lipopolysaccharides - pharmacology ; Membrane Glycoproteins - drug effects ; Mice ; Mice, Congenic ; Mice, Inbred NOD ; NOD ; RNA, Messenger - drug effects ; Time Factors
É parte de: Annals of the New York Academy of Sciences, 2004-12, Vol.1037 (1), p.186-192
Notas: istex:E6E556F32FBC0C4E64BDC0C13D44E54335F4ED29
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content type line 23
Descrição: : 1,25‐dihydroxyvitamin D3 [1,25(OH)2D3] prevents autoimmune diabetes in nonobese diabetic (NOD) mice. A major target for 1,25(OH)2D3 in the immune system is the dendritic cell (DC). Since important DC abnormalities have been described in NOD mice, we investigated the effects of 1,25(OH)2D3 on the yield and phenotype of DCs generated from bone marrow of NOD mice compared to control congenic nonobese diabetes‐resistant (NOR) mice. In both mouse strains, exposure of the bone marrow‐derived cells to 1,25(OH)2D3 increased the proportion of CD11c+ DCs after culture. Surface expression of MHC II, CD86, and CD54 on NOR‐derived DCs was decreased after 1,25(OH)2D3 treatment, while CD40 remained unchanged. On NOD‐derived DCs, 1,25(OH)2D3 only inhibited the expression of MHC II and CD86. 1,25(OH)2D3 inhibited IL‐12 and IL‐10 secretion after IFNγ and LPS stimulation. In vitro treatment with 1,25(OH)2D3 alters DC yield from bone marrow cultures and alters the phenotype of the cells in NOD as well as in NOR mice. NOD‐derived DCs were more resistant to the 1,25(OH)2D3 effects than were NOR‐derived DCs.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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1,25-Dihydroxyvitamin D3 Alters the Profile of Bone Marrow-Derived Dendritic Cells of NOD Mice

VAN ETTEN, EVELYNE ; DARDENNE, OLIVIER ; GYSEMANS, CONNY ; OVERBERGH, LUT ; MATHIEU, CHANTAL

Oxford, UK: Blackwell Publishing Ltd

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