Idioma:

Female Gender and Carcinoma In Situ in the Prostatic Urethra Are Prognostic Factors for Recurrence, Progression, and Disease-Specific Mortality in T1G3 Bladder Cancer Patients Treated With Bacillus Calmette-Guérin

Palou, Joan ; Sylvester, Richard J ; Faba, Oscar Rodríguez ; Parada, Rubén ; Peña, Juan A ; Algaba, Ferran ; Villavicencio, Humberto

European urology, 2012-07, Vol.62 (1), p.118-125 [Periódico revisado por pares]

Switzerland: Elsevier B.V

Texto completo disponível

Citações Citado por

Enviar para

Título:
Female Gender and Carcinoma In Situ in the Prostatic Urethra Are Prognostic Factors for Recurrence, Progression, and Disease-Specific Mortality in T1G3 Bladder Cancer Patients Treated With Bacillus Calmette-Guérin
Autor: Palou, Joan ; Sylvester, Richard J ; Faba, Oscar Rodríguez ; Parada, Rubén ; Peña, Juan A ; Algaba, Ferran ; Villavicencio, Humberto
Assuntos: Adjuvants, Immunologic - therapeutic use ; Adult ; Aged ; Aged, 80 and over ; Bacillus Calmette-Guèrin ; BCG Vaccine - therapeutic use ; Bladder carcinoma ; Carcinoma in Situ - mortality ; Carcinoma in Situ - pathology ; Carcinoma in Situ - surgery ; Carcinoma in Situ - therapy ; Cystectomy - methods ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Recurrence, Local - mortality ; Prognosis ; Prostate - pathology ; Retrospective Studies ; Sex Factors ; Survival Analysis ; T1G3 urothelial cancer ; Treatment Outcome ; Urethra - pathology ; Urinary Bladder Neoplasms - mortality ; Urinary Bladder Neoplasms - pathology ; Urinary Bladder Neoplasms - surgery ; Urinary Bladder Neoplasms - therapy ; Urology
É parte de: European urology, 2012-07, Vol.62 (1), p.118-125
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Abstract Background Controversy exists over the most important prognostic factors in T1 high-grade non–muscle-invasive bladder cancer (NMIBC) patients treated with bacillus Calmette-Guérin (BCG). Objective Evaluate prognostic factors for recurrence, progression, and disease-specific mortality after adjuvant intravesical BCG immunotherapy in patients with T1G3 NMIBC and long-term follow-up. Design, setting, and participants A single-institution retrospective analysis of 146 patients with primary stage T1G3 NMIBC. Intervention All patients were treated with complete transurethral resection (TUR) plus multiple bladder biopsies that included the prostatic urethra. No second TUR was done. Patients underwent an induction course of intravesical BCG (Connaught strain, 81 mg) without maintenance therapy. Measurements The variables analysed for time to recurrence, progression, and death due to bladder cancer (BCa) were gender, age, tumour multiplicity, diameter, aspect, substaging, concomitant carcinoma in situ (CIS), and CIS in the prostatic urethra. Cox regression models were used to assess the univariate and multivariate prognostic importance of these factors and estimate hazard ratios (HRs). Time-to-event distributions were estimated using cumulative incidence functions. Results and limitations The median follow-up was 8.7 yr. Sixty-five patients (44.5%) had recurrence, 25 patients (17.1%) had progression, and 18 patients (12.3%) died because of BCa. Female gender and presence of CIS in the prostatic urethra were associated with an increased risk of recurrence ( p = 0.0003, HR: 2.53), progression ( p = 0.001, HR: 3.59), and death due to BCa ( p = 0.004, HR: 3.53). Conclusions In primary T1G3 bladder tumours treated with induction BCG, female gender or having CIS in the prostatic urethra were the only prognostic factors for time to recurrence, progression, and disease-related mortality. It is very important to perform a biopsy of the prostatic urethra in patients with primary high-grade NMIBC as a first step to obtain this prognostic information.
Editor: Switzerland: Elsevier B.V
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 30 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Female Gender and Carcinoma In Situ in the Prostatic Urethra Are Prognostic Factors for Recurrence, Progression, and Disease-Specific Mortality in T1G3 Bladder Cancer Patients Treated With Bacillus Calmette-Guérin

Palou, Joan ; Sylvester, Richard J ; Faba, Oscar Rodríguez ; Parada, Rubén ; Peña, Juan A ; Algaba, Ferran ; Villavicencio, Humberto

Switzerland: Elsevier B.V

Buscando em bases de dados remotas. Favor aguardar.