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Distribution of hyaluronan and versican in mice embryos during organogenesis

Carlos Alberto Miqueloto Telma Maria Tenório Zorn; Congress of the Brazilian Society for Cell Biology (12. 2004 Campinas); Ibero-American Congress of Cell Biology (9. 2004 Campinas)

Abstracts Campinas, SP

Campinas 2004

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  • Título:
    Distribution of hyaluronan and versican in mice embryos during organogenesis
  • Autor: Carlos Alberto Miqueloto
  • Telma Maria Tenório Zorn; Congress of the Brazilian Society for Cell Biology (12. 2004 Campinas); Ibero-American Congress of Cell Biology (9. 2004 Campinas)
  • Assuntos: HISTOLOGIA
  • É parte de: Abstracts Campinas, SP
  • Notas Locais: Disponível em CD-ROM
  • Descrição: Embryonic development is a complex process that constitutes an excellent model for the study of extracellular matrix (ECM) molecules. Considering the biological characteristics of glycosaminoglycans and proteoglycans we may expect that they play a role during embryonic organogenesis. Hyaluronan (HA) is important as space filler during embryonic development. HA also participate in chemical signaling between cells. Versican (VER) regulates the cell survival, proliferation and migration and participates in the structural reorganization of ECM molecules, necessary for the development and maintenance of the tissues during embryonic development. This work shows the distribution of AH and VER in embryonic tissue of mice from E9 to E15 stages. Embryos on E9 to E15 stages of the development were fixed in Methacarn. HA and VER was localized by immunocytochemistry using specific antibodies. Both HA and VER were present in embryonic tissues in all developmental stages. HA was distributed in the extracellular spaces of connective tissues whereas VER was present around connective tissue cells and epithelial cells. Both molecules were present in the epithelial/mesenchymal interface. Both HA and VER are expressed in the connective and epithelial interface suggesting that these molecules play a role in the establishment of epithelial/mesenchymal interactions. The presence of these molecules in the early stages of the embryonic development indicates that both
    participate in the morphogenesis and organogenesis of mice
  • Editor: Campinas
  • Data de criação/publicação: 2004
  • Formato: [s. p.].
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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